Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges
Gastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced stage. Clinical trials show that neoadjuva...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-09-01
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| Series: | Chronic Diseases and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095882X20300359 |
| _version_ | 1811227949337149440 |
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| author | Zhi Zhu Ying-Bo Gong Hui-Mian Xu |
| author_facet | Zhi Zhu Ying-Bo Gong Hui-Mian Xu |
| author_sort | Zhi Zhu |
| collection | DOAJ |
| description | Gastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced stage. Clinical trials show that neoadjuvant approaches confer a significant survival advantage for resectable locally advanced gastric cancer. The specific advantages of chemoradiotherapy compared with chemotherapy have not been clarified; optimal regimens and cycles, particularly in the preoperative setting, should be studied further; and trials aimed at determining the role of targeted and immunological therapies should be conducted. |
| first_indexed | 2024-04-12T09:50:19Z |
| format | Article |
| id | doaj.art-dae57b02a2fb4e8a99c0555b5a042a44 |
| institution | Directory Open Access Journal |
| issn | 2095-882X |
| language | English |
| last_indexed | 2024-04-12T09:50:19Z |
| publishDate | 2020-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Chronic Diseases and Translational Medicine |
| spelling | doaj.art-dae57b02a2fb4e8a99c0555b5a042a442022-12-22T03:37:50ZengWileyChronic Diseases and Translational Medicine2095-882X2020-09-0163147157Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challengesZhi Zhu0Ying-Bo Gong1Hui-Mian Xu2Department of Surgical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, ChinaDepartment of Surgical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, ChinaCorresponding author. Department of Surgical Oncology, The First Hospital of China Medical University, North Nanjing Street 155, Shenyang, Liaoning 110001, China.; Department of Surgical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, ChinaGastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced stage. Clinical trials show that neoadjuvant approaches confer a significant survival advantage for resectable locally advanced gastric cancer. The specific advantages of chemoradiotherapy compared with chemotherapy have not been clarified; optimal regimens and cycles, particularly in the preoperative setting, should be studied further; and trials aimed at determining the role of targeted and immunological therapies should be conducted.http://www.sciencedirect.com/science/article/pii/S2095882X20300359Gastric cancerNeoadjuvant therapyChemotherapyRadiotherapy |
| spellingShingle | Zhi Zhu Ying-Bo Gong Hui-Mian Xu Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges Chronic Diseases and Translational Medicine Gastric cancer Neoadjuvant therapy Chemotherapy Radiotherapy |
| title | Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges |
| title_full | Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges |
| title_fullStr | Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges |
| title_full_unstemmed | Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges |
| title_short | Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges |
| title_sort | neoadjuvant therapy strategies for advanced gastric cancer current innovations and future challenges |
| topic | Gastric cancer Neoadjuvant therapy Chemotherapy Radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2095882X20300359 |
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