Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms
Abstract The morpho-functional properties of neural networks constantly adapt in response to environmental stimuli. The olfactory bulb is particularly prone to constant reshaping of neural networks because of ongoing neurogenesis. It remains unclear whether the complexity of distinct odor-induced le...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-06115-7 |
| _version_ | 1797219697513463808 |
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| author | Aymeric Ferreira Vlad-Stefan Constantinescu Sarah Malvaut Armen Saghatelyan Simon V. Hardy |
| author_facet | Aymeric Ferreira Vlad-Stefan Constantinescu Sarah Malvaut Armen Saghatelyan Simon V. Hardy |
| author_sort | Aymeric Ferreira |
| collection | DOAJ |
| description | Abstract The morpho-functional properties of neural networks constantly adapt in response to environmental stimuli. The olfactory bulb is particularly prone to constant reshaping of neural networks because of ongoing neurogenesis. It remains unclear whether the complexity of distinct odor-induced learning paradigms and sensory stimulation induces different forms of structural plasticity. In the present study, we automatically reconstructed spines in 3D from confocal images and performed unsupervised clustering based on morphometric features. We show that while sensory deprivation decreased the spine density of adult-born neurons without affecting the morphometric properties of these spines, simple and complex odor learning paradigms triggered distinct forms of structural plasticity. A simple odor learning task affected the morphometric properties of the spines, whereas a complex odor learning task induced changes in spine density. Our work reveals distinct forms of structural plasticity in the olfactory bulb tailored to the complexity of odor-learning paradigms and sensory inputs. |
| first_indexed | 2024-04-24T12:37:46Z |
| format | Article |
| id | doaj.art-dae58e012d29457a96424092efc462c1 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-24T12:37:46Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-dae58e012d29457a96424092efc462c12024-04-07T11:27:24ZengNature PortfolioCommunications Biology2399-36422024-04-017111510.1038/s42003-024-06115-7Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigmsAymeric Ferreira0Vlad-Stefan Constantinescu1Sarah Malvaut2Armen Saghatelyan3Simon V. Hardy4CERVO Brain Research CenterCERVO Brain Research CenterCERVO Brain Research CenterCERVO Brain Research CenterCERVO Brain Research CenterAbstract The morpho-functional properties of neural networks constantly adapt in response to environmental stimuli. The olfactory bulb is particularly prone to constant reshaping of neural networks because of ongoing neurogenesis. It remains unclear whether the complexity of distinct odor-induced learning paradigms and sensory stimulation induces different forms of structural plasticity. In the present study, we automatically reconstructed spines in 3D from confocal images and performed unsupervised clustering based on morphometric features. We show that while sensory deprivation decreased the spine density of adult-born neurons without affecting the morphometric properties of these spines, simple and complex odor learning paradigms triggered distinct forms of structural plasticity. A simple odor learning task affected the morphometric properties of the spines, whereas a complex odor learning task induced changes in spine density. Our work reveals distinct forms of structural plasticity in the olfactory bulb tailored to the complexity of odor-learning paradigms and sensory inputs.https://doi.org/10.1038/s42003-024-06115-7 |
| spellingShingle | Aymeric Ferreira Vlad-Stefan Constantinescu Sarah Malvaut Armen Saghatelyan Simon V. Hardy Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms Communications Biology |
| title | Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms |
| title_full | Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms |
| title_fullStr | Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms |
| title_full_unstemmed | Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms |
| title_short | Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms |
| title_sort | distinct forms of structural plasticity of adult born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms |
| url | https://doi.org/10.1038/s42003-024-06115-7 |
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