The potential application of natural products in cutaneous wound healing: A review of preclinical evidence
Under normal circumstances, wound healing can be summarized as three processes. These include inflammation, proliferation, and remodeling. The vast majority of wounds heal rapidly; however, a large percentage of nonhealing wounds have still not been studied significantly. The factors affecting wound...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.900439/full |
| _version_ | 1828261894599737344 |
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| author | E Liu Hongjin Gao YiJia Zhao Yaobing Pang Yejing Yao Zhengru Yang Xueer Zhang YanJin Wang Siming Yang Xiao Ma Jinhao Zeng Jing Guo |
| author_facet | E Liu Hongjin Gao YiJia Zhao Yaobing Pang Yejing Yao Zhengru Yang Xueer Zhang YanJin Wang Siming Yang Xiao Ma Jinhao Zeng Jing Guo |
| author_sort | E Liu |
| collection | DOAJ |
| description | Under normal circumstances, wound healing can be summarized as three processes. These include inflammation, proliferation, and remodeling. The vast majority of wounds heal rapidly; however, a large percentage of nonhealing wounds have still not been studied significantly. The factors affecting wound nonhealing are complex and diverse, and identifying an effective solution from nature becomes a key goal of research. This study aimed to highlight and review the mechanisms and targets of natural products (NPs) for treating nonhealing wounds. The results of relevant studies have shown that the effects of NPs are associated with PI3K-AKT, P38MAPK, fibroblast growth factor, MAPK, and ERK signaling pathways and involve tumor growth factor (TNF), vascular endothelial growth factor, TNF-α, interleukin-1β, and expression of other cytokines and proteins. The 25 NPs that contribute to wound healing were systematically summarized by an inductive collation of the six major classes of compounds, including saponins, polyphenols, flavonoids, anthraquinones, polysaccharides, and others, which will further direct the attention to the active components of NPs and provide research ideas for further development of new products for wound healing. |
| first_indexed | 2024-04-13T03:47:21Z |
| format | Article |
| id | doaj.art-dae745db5b144c8b818a7529ca8ca363 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T03:47:21Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-dae745db5b144c8b818a7529ca8ca3632022-12-22T03:03:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-07-011310.3389/fphar.2022.900439900439The potential application of natural products in cutaneous wound healing: A review of preclinical evidenceE Liu0Hongjin Gao1YiJia Zhao2Yaobing Pang3Yejing Yao4Zhengru Yang5Xueer Zhang6YanJin Wang7Siming Yang8Xiao Ma9Jinhao Zeng10Jing Guo11Dermatological Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDermatological Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDermatological Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDermatological Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaNeijiang Hospital of Traditional Chinese Medicine, Neijiang, ChinaDermatological Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDermatological Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDermatological Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDermatological Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDermatological Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaUnder normal circumstances, wound healing can be summarized as three processes. These include inflammation, proliferation, and remodeling. The vast majority of wounds heal rapidly; however, a large percentage of nonhealing wounds have still not been studied significantly. The factors affecting wound nonhealing are complex and diverse, and identifying an effective solution from nature becomes a key goal of research. This study aimed to highlight and review the mechanisms and targets of natural products (NPs) for treating nonhealing wounds. The results of relevant studies have shown that the effects of NPs are associated with PI3K-AKT, P38MAPK, fibroblast growth factor, MAPK, and ERK signaling pathways and involve tumor growth factor (TNF), vascular endothelial growth factor, TNF-α, interleukin-1β, and expression of other cytokines and proteins. The 25 NPs that contribute to wound healing were systematically summarized by an inductive collation of the six major classes of compounds, including saponins, polyphenols, flavonoids, anthraquinones, polysaccharides, and others, which will further direct the attention to the active components of NPs and provide research ideas for further development of new products for wound healing.https://www.frontiersin.org/articles/10.3389/fphar.2022.900439/fullnatural productswound healingskininflammationproliferationremodeling |
| spellingShingle | E Liu Hongjin Gao YiJia Zhao Yaobing Pang Yejing Yao Zhengru Yang Xueer Zhang YanJin Wang Siming Yang Xiao Ma Jinhao Zeng Jing Guo The potential application of natural products in cutaneous wound healing: A review of preclinical evidence Frontiers in Pharmacology natural products wound healing skin inflammation proliferation remodeling |
| title | The potential application of natural products in cutaneous wound healing: A review of preclinical evidence |
| title_full | The potential application of natural products in cutaneous wound healing: A review of preclinical evidence |
| title_fullStr | The potential application of natural products in cutaneous wound healing: A review of preclinical evidence |
| title_full_unstemmed | The potential application of natural products in cutaneous wound healing: A review of preclinical evidence |
| title_short | The potential application of natural products in cutaneous wound healing: A review of preclinical evidence |
| title_sort | potential application of natural products in cutaneous wound healing a review of preclinical evidence |
| topic | natural products wound healing skin inflammation proliferation remodeling |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.900439/full |
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