Alpha-tocopheryl succinate and doxorubicin-loaded liposomes improve drug uptake and tumor accumulation in a murine breast tumor model

Alpha-tocopheryl succinate and doxorubicin-loaded liposomes improve drug uptake and tumor accumulation in a murine breast tumor model

Liposomes composed of a rigid bilayer have high plasma stability; however, they can be challenged in efficacy due to complications in releasing the encapsulated drug as well as being internalized by the tumor cell. On the other hand, fusogenic liposomes may fuse with the plasmatic membrane and relea...

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Bibliographic Details
Main Authors: Fernanda A. Boratto, Eduardo B. Lages, Cristina M.C. Loures, Adriano P. Sabino, Angelo Malachias, Danyelle M. Townsend, Andre Luis Branco De Barros, Lucas Antonio Miranda Ferreira, Elaine Amaral Leite
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Doxorubicin
Alpha-tocopheryl succinate
PH-sensitive liposomes
Tumor accumulation
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223008247

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http://www.sciencedirect.com/science/article/pii/S0753332223008247

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