Electric field causes volumetric changes in the human brain
Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determ...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-10-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/49115 |
| _version_ | 1818023838833704960 |
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| author | Miklos Argyelan Leif Oltedal Zhi-De Deng Benjamin Wade Marom Bikson Andrea Joanlanne Sohag Sanghani Hauke Bartsch Marta Cano Anders M Dale Udo Dannlowski Annemiek Dols Verena Enneking Randall Espinoza Ute Kessler Katherine L Narr Ketil J Oedegaard Mardien L Oudega Ronny Redlich Max L Stek Akihiro Takamiya Louise Emsell Filip Bouckaert Pascal Sienaert Jesus Pujol Indira Tendolkar Philip van Eijndhoven Georgios Petrides Anil K Malhotra Christopher Abbott |
| author_facet | Miklos Argyelan Leif Oltedal Zhi-De Deng Benjamin Wade Marom Bikson Andrea Joanlanne Sohag Sanghani Hauke Bartsch Marta Cano Anders M Dale Udo Dannlowski Annemiek Dols Verena Enneking Randall Espinoza Ute Kessler Katherine L Narr Ketil J Oedegaard Mardien L Oudega Ronny Redlich Max L Stek Akihiro Takamiya Louise Emsell Filip Bouckaert Pascal Sienaert Jesus Pujol Indira Tendolkar Philip van Eijndhoven Georgios Petrides Anil K Malhotra Christopher Abbott |
| author_sort | Miklos Argyelan |
| collection | DOAJ |
| description | Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion. |
| first_indexed | 2024-12-10T03:50:41Z |
| format | Article |
| id | doaj.art-daea3a79b56244ee8f7915b897450c29 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T03:50:41Z |
| publishDate | 2019-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-daea3a79b56244ee8f7915b897450c292022-12-22T02:03:16ZengeLife Sciences Publications LtdeLife2050-084X2019-10-01810.7554/eLife.49115Electric field causes volumetric changes in the human brainMiklos Argyelan0https://orcid.org/0000-0002-7254-1776Leif Oltedal1Zhi-De Deng2Benjamin Wade3Marom Bikson4Andrea Joanlanne5Sohag Sanghani6Hauke Bartsch7Marta Cano8https://orcid.org/0000-0003-0675-9483Anders M Dale9Udo Dannlowski10Annemiek Dols11Verena Enneking12Randall Espinoza13Ute Kessler14Katherine L Narr15Ketil J Oedegaard16Mardien L Oudega17Ronny Redlich18Max L Stek19Akihiro Takamiya20Louise Emsell21Filip Bouckaert22Pascal Sienaert23Jesus Pujol24Indira Tendolkar25Philip van Eijndhoven26Georgios Petrides27Anil K Malhotra28Christopher Abbott29Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States; Center for Neuroscience, Feinstein Institute for Medical Research, Manhasset, United States; Department of Psychiatry, Zucker School of Medicine, Hempstead, United StatesDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Radiology, Haukeland University Hospital, Mohn Medical Imaging and Visualization Centre, Bergen, NorwayExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, United StatesDepartment of Neurology, Ahmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, United StatesDepartment of Biomedical Engineering, The City College of the City University of New York, New York, United StatesDepartment of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United StatesDepartment of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United StatesDepartment of Radiology, Haukeland University Hospital, Mohn Medical Imaging and Visualization Centre, Bergen, Norway; Center for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, United StatesDepartment of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain; CIBERSAM, Carlos III Health Institute, Barcelona, SpainCenter for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, United States; Department of Radiology, University of California, San Diego, San Diego, United States; Department of Neurosciences, University of California, San Diego, San Diego, United StatesDepartment of Psychiatry and Psychotherapy, University of Muenster, Muenster, GermanyDepartment of Psychiatry, Amsterdam UMC, location VUmc, GGZinGeest, Old Age Psychiatry, Amsterdam Neuroscience, Amsterdam, NetherlandsDepartment of Psychiatry and Psychotherapy, University of Muenster, Muenster, GermanyDepartment of Neurology, University of California, Los Angeles, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United StatesDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, University of Bergen, Bergen, NorwayDepartment of Neurology, University of California, Los Angeles, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United StatesDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, University of Bergen, Bergen, NorwayDepartment of Psychiatry, Amsterdam UMC, location VUmc, GGZinGeest, Old Age Psychiatry, Amsterdam Neuroscience, Amsterdam, NetherlandsDepartment of Psychiatry and Psychotherapy, University of Muenster, Muenster, GermanyDepartment of Psychiatry, Amsterdam UMC, location VUmc, GGZinGeest, Old Age Psychiatry, Amsterdam Neuroscience, Amsterdam, NetherlandsDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Center for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Geriatric Psychiatry, University Psychiatric Center, KU Leuven, Leuven, BelgiumDepartment of Geriatric Psychiatry, University Psychiatric Center, KU Leuven, Leuven, Belgium; Academic center for ECT and Neurostimulation (AcCENT), University Psychiatric Center, KU Leuven, Kortenberg, BelgiumAcademic center for ECT and Neurostimulation (AcCENT), University Psychiatric Center, KU Leuven, Kortenberg, BelgiumCIBERSAM, Carlos III Health Institute, Barcelona, Spain; MRI Research Unit, Department of Radiology, Hospital del Mar, Barcelona, SpainDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands; Donders Institute for Brain Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, Netherlands; Faculty of Medicine and LVR Clinic for Psychiatry and Psychotherapy, University of Duisburg-Essen, Essen, GermanyDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands; Donders Institute for Brain Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, NetherlandsDepartment of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States; Center for Neuroscience, Feinstein Institute for Medical Research, Manhasset, United States; Department of Psychiatry, Zucker School of Medicine, Hempstead, United StatesDepartment of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States; Center for Neuroscience, Feinstein Institute for Medical Research, Manhasset, United States; Department of Psychiatry, Zucker School of Medicine, Hempstead, United StatesDepartment of Psychiatry, University of New Mexico School of Medicine, Albuquerque, United StatesRecent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.https://elifesciences.org/articles/49115electric field modelingvolume changeECTdepressionneuroimaging |
| spellingShingle | Miklos Argyelan Leif Oltedal Zhi-De Deng Benjamin Wade Marom Bikson Andrea Joanlanne Sohag Sanghani Hauke Bartsch Marta Cano Anders M Dale Udo Dannlowski Annemiek Dols Verena Enneking Randall Espinoza Ute Kessler Katherine L Narr Ketil J Oedegaard Mardien L Oudega Ronny Redlich Max L Stek Akihiro Takamiya Louise Emsell Filip Bouckaert Pascal Sienaert Jesus Pujol Indira Tendolkar Philip van Eijndhoven Georgios Petrides Anil K Malhotra Christopher Abbott Electric field causes volumetric changes in the human brain eLife electric field modeling volume change ECT depression neuroimaging |
| title | Electric field causes volumetric changes in the human brain |
| title_full | Electric field causes volumetric changes in the human brain |
| title_fullStr | Electric field causes volumetric changes in the human brain |
| title_full_unstemmed | Electric field causes volumetric changes in the human brain |
| title_short | Electric field causes volumetric changes in the human brain |
| title_sort | electric field causes volumetric changes in the human brain |
| topic | electric field modeling volume change ECT depression neuroimaging |
| url | https://elifesciences.org/articles/49115 |
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