Multivariate Analysis of Prognostic Factors in the Eldly Patients with Small Cell Lung Cancer: A Study of 160 Patients
Background and objective Lung cancer is currently the leading cause of cancer death, two thirds of patients are over the age of 65. Small cell lung cancer (SCLC) accounts for about 15%-20% of all lung cancer. The objective of this study is to evaluate the survival of patients older than 65 with SCLC...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2014-01-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2014.01.03 |
| _version_ | 1818033462327640064 |
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| author | Xiaoling CHEN Jian FANG Jun NIE Ling DAI Jie ZHANG Weiheng HU Jindi HAN Xiangjuan MA Guangming TIAN Sen HAN Di WU Jieran LONG Yang WANG |
| author_facet | Xiaoling CHEN Jian FANG Jun NIE Ling DAI Jie ZHANG Weiheng HU Jindi HAN Xiangjuan MA Guangming TIAN Sen HAN Di WU Jieran LONG Yang WANG |
| author_sort | Xiaoling CHEN |
| collection | DOAJ |
| description | Background and objective Lung cancer is currently the leading cause of cancer death, two thirds of patients are over the age of 65. Small cell lung cancer (SCLC) accounts for about 15%-20% of all lung cancer. The objective of this study is to evaluate the survival of patients older than 65 with SCLC and analyze the independent prognostic factors in this group of patients. Methods A retrospective study has enrolled 160 cases of lung cancer aged over 65. The prognostic factors were analyzed by Kaplan-Meier and Cox multivariate proportional hazards model. Results ① The median follow-up time was 12 (2-109) months. 1-, 3-, and 5-year survival rate was 47.1%, 13.0%, 9.6% respectively, and 74.4%, 25.0%, 19.7% for limited-stage (LD), and 36.8%, 8.7%, 5.8% for extensive-stage (ED). Median survival time (MST) of all the patients was 12 months, 24 months for LD and 11 months for ED, respectively. ② Multivariate analysis suggested that performance status (PS) pre-treatment, the change of PS after treatment, stage, liver metastases and thoracic radiotherapy were the independent prognostic factors in all patients. ③ For LD-SCLC patients, PS pre-treatment, thoracic radiotherapy were the independent prognostic factors. The model of thoracic radiotherapy (concurrent chemoradiation vs sequential chemoradiation, early concurrent chemoradiation vs late concurrent chemoradiation) and prophylactic cranial irradiation (PCI) did not show significant difference. ④ For ED-SCLC patients, sex, the change of PS after treatment, chemotherapy, liver metastases, thoracic radiotherapy, PCI were the independent prognostic factors. Conclusion The survival time is related to PS and thoracic radiotherapy in eldly patients. Besides, it is also related to sex, chemotherapy, liver metastases and PCI for ED-SCLC. |
| first_indexed | 2024-12-10T06:23:39Z |
| format | Article |
| id | doaj.art-daead9202c234b269aa4379327f23427 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 |
| language | zho |
| last_indexed | 2024-12-10T06:23:39Z |
| publishDate | 2014-01-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-daead9202c234b269aa4379327f234272022-12-22T01:59:16ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34192014-01-01171152310.3779/j.issn.1009-3419.2014.01.03Multivariate Analysis of Prognostic Factors in the Eldly Patients with Small Cell Lung Cancer: A Study of 160 PatientsXiaoling CHEN0Jian FANG1Jun NIE2Ling DAI3Jie ZHANG4Weiheng HU5Jindi HAN6Xiangjuan MA7Guangming TIAN8Sen HAN9Di WU10Jieran LONG11Yang WANG12Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, ChinaBackground and objective Lung cancer is currently the leading cause of cancer death, two thirds of patients are over the age of 65. Small cell lung cancer (SCLC) accounts for about 15%-20% of all lung cancer. The objective of this study is to evaluate the survival of patients older than 65 with SCLC and analyze the independent prognostic factors in this group of patients. Methods A retrospective study has enrolled 160 cases of lung cancer aged over 65. The prognostic factors were analyzed by Kaplan-Meier and Cox multivariate proportional hazards model. Results ① The median follow-up time was 12 (2-109) months. 1-, 3-, and 5-year survival rate was 47.1%, 13.0%, 9.6% respectively, and 74.4%, 25.0%, 19.7% for limited-stage (LD), and 36.8%, 8.7%, 5.8% for extensive-stage (ED). Median survival time (MST) of all the patients was 12 months, 24 months for LD and 11 months for ED, respectively. ② Multivariate analysis suggested that performance status (PS) pre-treatment, the change of PS after treatment, stage, liver metastases and thoracic radiotherapy were the independent prognostic factors in all patients. ③ For LD-SCLC patients, PS pre-treatment, thoracic radiotherapy were the independent prognostic factors. The model of thoracic radiotherapy (concurrent chemoradiation vs sequential chemoradiation, early concurrent chemoradiation vs late concurrent chemoradiation) and prophylactic cranial irradiation (PCI) did not show significant difference. ④ For ED-SCLC patients, sex, the change of PS after treatment, chemotherapy, liver metastases, thoracic radiotherapy, PCI were the independent prognostic factors. Conclusion The survival time is related to PS and thoracic radiotherapy in eldly patients. Besides, it is also related to sex, chemotherapy, liver metastases and PCI for ED-SCLC.http://dx.doi.org/10.3779/j.issn.1009-3419.2014.01.03Lung neoplsmsGeriatricsSurvivalPrognosis |
| spellingShingle | Xiaoling CHEN Jian FANG Jun NIE Ling DAI Jie ZHANG Weiheng HU Jindi HAN Xiangjuan MA Guangming TIAN Sen HAN Di WU Jieran LONG Yang WANG Multivariate Analysis of Prognostic Factors in the Eldly Patients with Small Cell Lung Cancer: A Study of 160 Patients Chinese Journal of Lung Cancer Lung neoplsms Geriatrics Survival Prognosis |
| title | Multivariate Analysis of Prognostic Factors in the Eldly Patients with Small Cell Lung Cancer: A Study of 160 Patients |
| title_full | Multivariate Analysis of Prognostic Factors in the Eldly Patients with Small Cell Lung Cancer: A Study of 160 Patients |
| title_fullStr | Multivariate Analysis of Prognostic Factors in the Eldly Patients with Small Cell Lung Cancer: A Study of 160 Patients |
| title_full_unstemmed | Multivariate Analysis of Prognostic Factors in the Eldly Patients with Small Cell Lung Cancer: A Study of 160 Patients |
| title_short | Multivariate Analysis of Prognostic Factors in the Eldly Patients with Small Cell Lung Cancer: A Study of 160 Patients |
| title_sort | multivariate analysis of prognostic factors in the eldly patients with small cell lung cancer a study of 160 patients |
| topic | Lung neoplsms Geriatrics Survival Prognosis |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2014.01.03 |
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