Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis
Immunopathogenesis of rheumatoid arthritis (RA) is characterized by polyclonal activation of B lymphocytes, changes in their subpopulation composition, impaired peripheral tolerance, increased activation and differentiation of B cells, as well as deficient negative selection. Peripheral blood phenot...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2020-01-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1808 |
| _version_ | 1797197913262129152 |
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| author | L. P. Sizyakina M. V. Kharitonova |
| author_facet | L. P. Sizyakina M. V. Kharitonova |
| author_sort | L. P. Sizyakina |
| collection | DOAJ |
| description | Immunopathogenesis of rheumatoid arthritis (RA) is characterized by polyclonal activation of B lymphocytes, changes in their subpopulation composition, impaired peripheral tolerance, increased activation and differentiation of B cells, as well as deficient negative selection. Peripheral blood phenotypes of B1 and B2 lymphocytes, their correlation and response patterns in seronegative variant of articular RA type A decrease in B1 lymphocytes along with increased degree of clinical activity and duration of RA has been revealed. B2 lymphocytes remained the predominant subpopulation in peripheral blood. The studied parameters of B2 lymphocytes in the patients with disease duration of up to 5 years and more were higher than the data obtained in a control group. However, no significant changes in their dynamics were revealed upon comparative analysis. With increasing degree of clinical activity, the decreased activation potential of B2 lymphocytes was revealed, along with reduction of costimulatory signal transmission via the CD40/CD40L complex. Hence, detection of B1 and B2 lymphocytes in various types of RA may be used as diagnostic and prognostic markers. |
| first_indexed | 2024-03-08T05:49:10Z |
| format | Article |
| id | doaj.art-daeb15ec4a6f4bc1a2b9c0dd03260342 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:51:31Z |
| publishDate | 2020-01-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-daeb15ec4a6f4bc1a2b9c0dd032603422024-04-22T13:07:44ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2020-01-012161073108010.15789/1563-0625-2019-6-1073-10801228Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritisL. P. Sizyakina0M. V. Kharitonova1Rostov State Medical UniversityRostov State Medical UniversityImmunopathogenesis of rheumatoid arthritis (RA) is characterized by polyclonal activation of B lymphocytes, changes in their subpopulation composition, impaired peripheral tolerance, increased activation and differentiation of B cells, as well as deficient negative selection. Peripheral blood phenotypes of B1 and B2 lymphocytes, their correlation and response patterns in seronegative variant of articular RA type A decrease in B1 lymphocytes along with increased degree of clinical activity and duration of RA has been revealed. B2 lymphocytes remained the predominant subpopulation in peripheral blood. The studied parameters of B2 lymphocytes in the patients with disease duration of up to 5 years and more were higher than the data obtained in a control group. However, no significant changes in their dynamics were revealed upon comparative analysis. With increasing degree of clinical activity, the decreased activation potential of B2 lymphocytes was revealed, along with reduction of costimulatory signal transmission via the CD40/CD40L complex. Hence, detection of B1 and B2 lymphocytes in various types of RA may be used as diagnostic and prognostic markers.https://www.mimmun.ru/mimmun/article/view/1808seronegative rheumatoid arthritisb1 cellsb2 cellsco-stimulating moleculesflow cytometry |
| spellingShingle | L. P. Sizyakina M. V. Kharitonova Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis Медицинская иммунология seronegative rheumatoid arthritis b1 cells b2 cells co-stimulating molecules flow cytometry |
| title | Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis |
| title_full | Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis |
| title_fullStr | Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis |
| title_full_unstemmed | Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis |
| title_short | Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis |
| title_sort | dynamics of changes in b1 and b2 lymphocyte populations in articular form of seronegative rheumatoid arthritis |
| topic | seronegative rheumatoid arthritis b1 cells b2 cells co-stimulating molecules flow cytometry |
| url | https://www.mimmun.ru/mimmun/article/view/1808 |
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