Measuring latency distribution of transcallosal fibers using transcranial magnetic stimulation
Background: Neuroimaging technology is being developed to enable non-invasive mapping of the latency distribution of cortical projection pathways in white matter, and correlative clinical neurophysiological techniques would be valuable for mutual verification. Interhemispheric interaction through th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Brain Stimulation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X20302229 |
| _version_ | 1818607941281906688 |
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| author | Zhen Ni Giorgio Leodori Felipe Vial Yong Zhang Alexandru V. Avram Sinisa Pajevic Peter J. Basser Mark Hallett |
| author_facet | Zhen Ni Giorgio Leodori Felipe Vial Yong Zhang Alexandru V. Avram Sinisa Pajevic Peter J. Basser Mark Hallett |
| author_sort | Zhen Ni |
| collection | DOAJ |
| description | Background: Neuroimaging technology is being developed to enable non-invasive mapping of the latency distribution of cortical projection pathways in white matter, and correlative clinical neurophysiological techniques would be valuable for mutual verification. Interhemispheric interaction through the corpus callosum can be measured with interhemispheric facilitation and inhibition using transcranial magnetic stimulation. Objective: To develop a method for determining the latency distribution of the transcallosal fibers with transcranial magnetic stimulation. Methods: We measured the precise time courses of interhemispheric facilitation and inhibition with a conditioning-test paired-pulse magnetic stimulation paradigm. The conditioning stimulus was applied to the right primary motor cortex and the test stimulus was applied to the left primary motor cortex. The interstimulus interval was set at 0.1 ms resolution. The proportions of transcallosal fibers with different conduction velocities were calculated by measuring the changes in magnitudes of interhemispheric facilitation and inhibition with interstimulus interval. Results: Both interhemispheric facilitation and inhibition increased with increment in interstimulus interval. The magnitude of interhemispheric facilitation was correlated with that of interhemispheric inhibition. The latency distribution of transcallosal fibers measured with interhemispheric facilitation was also correlated with that measured with interhemispheric inhibition. Conclusions: The data can be interpreted as latency distribution of transcallosal fibers. Interhemispheric interaction measured with transcranial magnetic stimulation is a promising technique to determine the latency distribution of the transcallosal fibers. Similar techniques could be developed for other cortical pathways. |
| first_indexed | 2024-12-16T14:34:45Z |
| format | Article |
| id | doaj.art-daebf5a98d594a498237c069db14bb3c |
| institution | Directory Open Access Journal |
| issn | 1935-861X |
| language | English |
| last_indexed | 2024-12-16T14:34:45Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj.art-daebf5a98d594a498237c069db14bb3c2022-12-21T22:28:08ZengElsevierBrain Stimulation1935-861X2020-09-0113514531460Measuring latency distribution of transcallosal fibers using transcranial magnetic stimulationZhen Ni0Giorgio Leodori1Felipe Vial2Yong Zhang3Alexandru V. Avram4Sinisa Pajevic5Peter J. Basser6Mark Hallett7Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, USAIRCCS Neuromed, Pozzilli, ItalyHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA; Facultad de Medicina Clinica Alemana Universidad Del Desarrollo, Santiago, ChileHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, USANational Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, USASection on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, USASection on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, USAHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA; Corresponding author. Human Motor Control Section, NINDS, NIH, Building 10, Room 7D37, 10 Center Dr. MSC 1428, Bethesda, MD, USA.Background: Neuroimaging technology is being developed to enable non-invasive mapping of the latency distribution of cortical projection pathways in white matter, and correlative clinical neurophysiological techniques would be valuable for mutual verification. Interhemispheric interaction through the corpus callosum can be measured with interhemispheric facilitation and inhibition using transcranial magnetic stimulation. Objective: To develop a method for determining the latency distribution of the transcallosal fibers with transcranial magnetic stimulation. Methods: We measured the precise time courses of interhemispheric facilitation and inhibition with a conditioning-test paired-pulse magnetic stimulation paradigm. The conditioning stimulus was applied to the right primary motor cortex and the test stimulus was applied to the left primary motor cortex. The interstimulus interval was set at 0.1 ms resolution. The proportions of transcallosal fibers with different conduction velocities were calculated by measuring the changes in magnitudes of interhemispheric facilitation and inhibition with interstimulus interval. Results: Both interhemispheric facilitation and inhibition increased with increment in interstimulus interval. The magnitude of interhemispheric facilitation was correlated with that of interhemispheric inhibition. The latency distribution of transcallosal fibers measured with interhemispheric facilitation was also correlated with that measured with interhemispheric inhibition. Conclusions: The data can be interpreted as latency distribution of transcallosal fibers. Interhemispheric interaction measured with transcranial magnetic stimulation is a promising technique to determine the latency distribution of the transcallosal fibers. Similar techniques could be developed for other cortical pathways.http://www.sciencedirect.com/science/article/pii/S1935861X20302229Corpus callosumInterhemispheric facilitation and interhemispheric inhibitionLatency distributionMotor evoked potentialPrimary motor cortexTranscranial magnetic stimulation |
| spellingShingle | Zhen Ni Giorgio Leodori Felipe Vial Yong Zhang Alexandru V. Avram Sinisa Pajevic Peter J. Basser Mark Hallett Measuring latency distribution of transcallosal fibers using transcranial magnetic stimulation Brain Stimulation Corpus callosum Interhemispheric facilitation and interhemispheric inhibition Latency distribution Motor evoked potential Primary motor cortex Transcranial magnetic stimulation |
| title | Measuring latency distribution of transcallosal fibers using transcranial magnetic stimulation |
| title_full | Measuring latency distribution of transcallosal fibers using transcranial magnetic stimulation |
| title_fullStr | Measuring latency distribution of transcallosal fibers using transcranial magnetic stimulation |
| title_full_unstemmed | Measuring latency distribution of transcallosal fibers using transcranial magnetic stimulation |
| title_short | Measuring latency distribution of transcallosal fibers using transcranial magnetic stimulation |
| title_sort | measuring latency distribution of transcallosal fibers using transcranial magnetic stimulation |
| topic | Corpus callosum Interhemispheric facilitation and interhemispheric inhibition Latency distribution Motor evoked potential Primary motor cortex Transcranial magnetic stimulation |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X20302229 |
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