Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure
<p>Abstract</p> <p>Introduction</p> <p>Inotropes are associated with adverse outcomes in heart failure (HF), raising concern they may accelerate myocardial injury. Whether biomarkers of myocardial necrosis, inflammation and apoptosis change in response to acute milrinon...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-07-01
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| Series: | Journal of Translational Medicine |
| Online Access: | http://www.translational-medicine.com/content/7/1/67 |
| _version_ | 1828465641601892352 |
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| author | Tita Cristina Czerska Barbara Williams Celeste Gupta Ramesh C Hasan Reema Lanfear David E Bazari Rasha Sabbah Hani N |
| author_facet | Tita Cristina Czerska Barbara Williams Celeste Gupta Ramesh C Hasan Reema Lanfear David E Bazari Rasha Sabbah Hani N |
| author_sort | Tita Cristina |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>Inotropes are associated with adverse outcomes in heart failure (HF), raising concern they may accelerate myocardial injury. Whether biomarkers of myocardial necrosis, inflammation and apoptosis change in response to acute milrinone administration is not well established.</p> <p>Methods</p> <p>Ten patients with severe HF and reduced cardiac output who were to receive milrinone were studied. Blood samples were taken just before initiation of milrinone and after 24 hours of infusion. Dosing was at the discretion of the patient's attending physician (range 0.25–0.5 mcg/kg/min). Plasma measurements of troponin, myoglobin, N-terminal-pro-BNP, interleukin-6, tumor necrosis factor-α, soluble Fas, and soluble Fas-ligand were performed at both time points.</p> <p>Results</p> <p>Troponin was elevated at baseline in all patients (mean 0.1259 ± 0.17 ng/ml), but there was no significant change after 24 hours of milrinone (mean 0.1345 ± 0.16 ng/ml, p = 0.44). There were significant improvements in interleukin-6, tumor necrosis factor-α, soluble Fas, and soluble Fas-ligand (all p < 0.05) indicative of reduced inflammatory and apoptotic signaling compared to baseline.</p> <p>Conclusion</p> <p>In conclusion, among patients with severe HF and low cardiac output, ongoing myocardial injury is common, and initiation of milrinone did not result in exacerbation of myocardial injury but instead was associated with salutary effects on other biomarkers.</p> |
| first_indexed | 2024-12-11T03:37:10Z |
| format | Article |
| id | doaj.art-daec3d196cc34c7f8d2ed1cdf6fcad39 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-11T03:37:10Z |
| publishDate | 2009-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-daec3d196cc34c7f8d2ed1cdf6fcad392022-12-22T01:22:14ZengBMCJournal of Translational Medicine1479-58762009-07-01716710.1186/1479-5876-7-67Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failureTita CristinaCzerska BarbaraWilliams CelesteGupta Ramesh CHasan ReemaLanfear David EBazari RashaSabbah Hani N<p>Abstract</p> <p>Introduction</p> <p>Inotropes are associated with adverse outcomes in heart failure (HF), raising concern they may accelerate myocardial injury. Whether biomarkers of myocardial necrosis, inflammation and apoptosis change in response to acute milrinone administration is not well established.</p> <p>Methods</p> <p>Ten patients with severe HF and reduced cardiac output who were to receive milrinone were studied. Blood samples were taken just before initiation of milrinone and after 24 hours of infusion. Dosing was at the discretion of the patient's attending physician (range 0.25–0.5 mcg/kg/min). Plasma measurements of troponin, myoglobin, N-terminal-pro-BNP, interleukin-6, tumor necrosis factor-α, soluble Fas, and soluble Fas-ligand were performed at both time points.</p> <p>Results</p> <p>Troponin was elevated at baseline in all patients (mean 0.1259 ± 0.17 ng/ml), but there was no significant change after 24 hours of milrinone (mean 0.1345 ± 0.16 ng/ml, p = 0.44). There were significant improvements in interleukin-6, tumor necrosis factor-α, soluble Fas, and soluble Fas-ligand (all p < 0.05) indicative of reduced inflammatory and apoptotic signaling compared to baseline.</p> <p>Conclusion</p> <p>In conclusion, among patients with severe HF and low cardiac output, ongoing myocardial injury is common, and initiation of milrinone did not result in exacerbation of myocardial injury but instead was associated with salutary effects on other biomarkers.</p>http://www.translational-medicine.com/content/7/1/67 |
| spellingShingle | Tita Cristina Czerska Barbara Williams Celeste Gupta Ramesh C Hasan Reema Lanfear David E Bazari Rasha Sabbah Hani N Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure Journal of Translational Medicine |
| title | Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure |
| title_full | Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure |
| title_fullStr | Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure |
| title_full_unstemmed | Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure |
| title_short | Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure |
| title_sort | short term effects of milrinone on biomarkers of necrosis apoptosis and inflammation in patients with severe heart failure |
| url | http://www.translational-medicine.com/content/7/1/67 |
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