Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation

Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation

Among the various immunological and non-immunological tumor-promoting activities of myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity remains a key hallmark. Effort in the past decade has provided us with a clearer view of the suppressive nature of MDSCs. More suppressive pa...

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Bibliographic Details
Main Authors: Yuhui Yang, Chunyan Li, Tao Liu, Xiaofang Dai, Alexandr V. Bazhin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
myeloid-derived suppressor cells
immune suppression
tumor microenvironment
immunotherapy
endoplasmic reticulum stress
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01371/full

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