Structural-vascular-functional correlation in type 2 non-proliferative macular telangiectasia
Abstract Purpose To correlate the structural-vascular-functional changes in type 2 non-proliferative macular telangiectasia (MacTel) using optical coherence tomography (OCT) angiography (OCTA). Methods In this retrospective study, OCTA and enface OCT image analysis of eyes with confirmed diagnosis o...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | International Journal of Retina and Vitreous |
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| Online Access: | https://doi.org/10.1186/s40942-022-00410-3 |
| _version_ | 1817998923664457728 |
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| author | Ramesh Venkatesh Nikitha Gurram Reddy Pranjal Mishra Naresh Kumar Yadav Jay Chhablani |
| author_facet | Ramesh Venkatesh Nikitha Gurram Reddy Pranjal Mishra Naresh Kumar Yadav Jay Chhablani |
| author_sort | Ramesh Venkatesh |
| collection | DOAJ |
| description | Abstract Purpose To correlate the structural-vascular-functional changes in type 2 non-proliferative macular telangiectasia (MacTel) using optical coherence tomography (OCT) angiography (OCTA). Methods In this retrospective study, OCTA and enface OCT image analysis of eyes with confirmed diagnosis of non-proliferative type 2 MacTel was performed. The ‘MacTel area’ was calculated by marking the outer boundary of an area affected by MacTel on superficial (SCP) and deep capillary plexus (DCP) on OCTA images and photoreceptor layer (PRL) on enface OCT scan. At every follow-up OCTA scan visit, best-corrected visual acuity, MacTel area and stage of disease was documented. Analyses between disease stage, MacTel area and logMAR visual acuity was carried out. Results In total, 38 single-visit OCTA scans of 22 patients were included. The mean age was 58.9 ± 10.98 years. An increase in disease severity stage correlated positively with MacTel area in SCP segmentations slab (r = 0.334; p = 0.04) and logMAR visual acuity (r = 0.338; p = 0.038). No correlation in the DCP area or PRL area (p > 0.05) was noted with disease stage. A statistically significant positive correlation was noted between the structural changes in PRL layer with vascular changes in SCP (p = 0.021) but not in DCP (p = 0.199). No correlation of visual acuity with changes in SCP, DCP or PRL was noted (p > 0.05). Conclusion OCTA is a useful adjunct for determining disease severity in type 2 non-proliferative MacTel by assessing the structural-vascular changes. Further longitudinal studies need to be considered in future for understanding the pathomechanism of retinal damage in type 2 MacTel. |
| first_indexed | 2024-04-14T03:00:47Z |
| format | Article |
| id | doaj.art-daf33d0bd1b04a90a76a771353db3d8f |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-04-14T03:00:47Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-daf33d0bd1b04a90a76a771353db3d8f2022-12-22T02:15:55ZengBMCInternational Journal of Retina and Vitreous2056-99202022-08-01811910.1186/s40942-022-00410-3Structural-vascular-functional correlation in type 2 non-proliferative macular telangiectasiaRamesh Venkatesh0Nikitha Gurram Reddy1Pranjal Mishra2Naresh Kumar Yadav3Jay Chhablani4Narayana NethralayaNarayana NethralayaNarayana NethralayaNarayana NethralayaUniversity of Pittsburgh School of Medicine, Medical Retina and Vitreoretinal SurgeryAbstract Purpose To correlate the structural-vascular-functional changes in type 2 non-proliferative macular telangiectasia (MacTel) using optical coherence tomography (OCT) angiography (OCTA). Methods In this retrospective study, OCTA and enface OCT image analysis of eyes with confirmed diagnosis of non-proliferative type 2 MacTel was performed. The ‘MacTel area’ was calculated by marking the outer boundary of an area affected by MacTel on superficial (SCP) and deep capillary plexus (DCP) on OCTA images and photoreceptor layer (PRL) on enface OCT scan. At every follow-up OCTA scan visit, best-corrected visual acuity, MacTel area and stage of disease was documented. Analyses between disease stage, MacTel area and logMAR visual acuity was carried out. Results In total, 38 single-visit OCTA scans of 22 patients were included. The mean age was 58.9 ± 10.98 years. An increase in disease severity stage correlated positively with MacTel area in SCP segmentations slab (r = 0.334; p = 0.04) and logMAR visual acuity (r = 0.338; p = 0.038). No correlation in the DCP area or PRL area (p > 0.05) was noted with disease stage. A statistically significant positive correlation was noted between the structural changes in PRL layer with vascular changes in SCP (p = 0.021) but not in DCP (p = 0.199). No correlation of visual acuity with changes in SCP, DCP or PRL was noted (p > 0.05). Conclusion OCTA is a useful adjunct for determining disease severity in type 2 non-proliferative MacTel by assessing the structural-vascular changes. Further longitudinal studies need to be considered in future for understanding the pathomechanism of retinal damage in type 2 MacTel.https://doi.org/10.1186/s40942-022-00410-3Macular telangiectasiaOptical coherence tomography angiographyDisease stagesNon-proliferative stageVisual outcomes |
| spellingShingle | Ramesh Venkatesh Nikitha Gurram Reddy Pranjal Mishra Naresh Kumar Yadav Jay Chhablani Structural-vascular-functional correlation in type 2 non-proliferative macular telangiectasia International Journal of Retina and Vitreous Macular telangiectasia Optical coherence tomography angiography Disease stages Non-proliferative stage Visual outcomes |
| title | Structural-vascular-functional correlation in type 2 non-proliferative macular telangiectasia |
| title_full | Structural-vascular-functional correlation in type 2 non-proliferative macular telangiectasia |
| title_fullStr | Structural-vascular-functional correlation in type 2 non-proliferative macular telangiectasia |
| title_full_unstemmed | Structural-vascular-functional correlation in type 2 non-proliferative macular telangiectasia |
| title_short | Structural-vascular-functional correlation in type 2 non-proliferative macular telangiectasia |
| title_sort | structural vascular functional correlation in type 2 non proliferative macular telangiectasia |
| topic | Macular telangiectasia Optical coherence tomography angiography Disease stages Non-proliferative stage Visual outcomes |
| url | https://doi.org/10.1186/s40942-022-00410-3 |
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