Outcome of autologous stem cell transplantation in patients with favorable-risk acute myeloid leukemia in first remission
Abstract Objective To evaluate the efficacy of autologous hematopoietic stem cell transplantation (auto-HSCT) in patients with favorable-risk acute myeloid leukemia in first remission. Method Twenty patients who received auto-HSCT at our center between January 2014 and January 2021 were retrospectiv...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02750-4 |
| _version_ | 1828155950306951168 |
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| author | Juan Chen Li Liu Runzhi Ma Aiming Pang Donglin Yang Xin Chen Jialin Wei Yi He Rongli Zhang Weihua Zhai Qiaoling Ma Erlie Jiang Mingzhe Han Jiaxi Zhou Sizhou Feng |
| author_facet | Juan Chen Li Liu Runzhi Ma Aiming Pang Donglin Yang Xin Chen Jialin Wei Yi He Rongli Zhang Weihua Zhai Qiaoling Ma Erlie Jiang Mingzhe Han Jiaxi Zhou Sizhou Feng |
| author_sort | Juan Chen |
| collection | DOAJ |
| description | Abstract Objective To evaluate the efficacy of autologous hematopoietic stem cell transplantation (auto-HSCT) in patients with favorable-risk acute myeloid leukemia in first remission. Method Twenty patients who received auto-HSCT at our center between January 2014 and January 2021 were retrospectively reviewed. Results Until last follow-up, three patients in the cohort were dead due to relapse. The estimated 1-year and 5-year overall survival were 95.00% ± 4.87% and 83.82% ± 8.58%, respectively. The estimated 5-year RFS and CIR (cumulative incidence of relapse) were 85.00% ± 7.98% and 15.00% ±7.98%, respectively. Conclusion The outcome of auto-HSCT in patients with favorable-risk acute myeloid leukemia in first remission was excellent and auto-HSCT could be an effective treatment for these patients. |
| first_indexed | 2024-04-11T23:02:08Z |
| format | Article |
| id | doaj.art-daf68aff4a9a4bbea3a36632183c352f |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-11T23:02:08Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-daf68aff4a9a4bbea3a36632183c352f2022-12-22T03:58:07ZengBMCCancer Cell International1475-28672022-10-012211610.1186/s12935-022-02750-4Outcome of autologous stem cell transplantation in patients with favorable-risk acute myeloid leukemia in first remissionJuan Chen0Li Liu1Runzhi Ma2Aiming Pang3Donglin Yang4Xin Chen5Jialin Wei6Yi He7Rongli Zhang8Weihua Zhai9Qiaoling Ma10Erlie Jiang11Mingzhe Han12Jiaxi Zhou13Sizhou Feng14State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeAbstract Objective To evaluate the efficacy of autologous hematopoietic stem cell transplantation (auto-HSCT) in patients with favorable-risk acute myeloid leukemia in first remission. Method Twenty patients who received auto-HSCT at our center between January 2014 and January 2021 were retrospectively reviewed. Results Until last follow-up, three patients in the cohort were dead due to relapse. The estimated 1-year and 5-year overall survival were 95.00% ± 4.87% and 83.82% ± 8.58%, respectively. The estimated 5-year RFS and CIR (cumulative incidence of relapse) were 85.00% ± 7.98% and 15.00% ±7.98%, respectively. Conclusion The outcome of auto-HSCT in patients with favorable-risk acute myeloid leukemia in first remission was excellent and auto-HSCT could be an effective treatment for these patients.https://doi.org/10.1186/s12935-022-02750-4OutcomeAutologous stem cell transplantationAcute myeloid leukemiaFavorable-riskRemission |
| spellingShingle | Juan Chen Li Liu Runzhi Ma Aiming Pang Donglin Yang Xin Chen Jialin Wei Yi He Rongli Zhang Weihua Zhai Qiaoling Ma Erlie Jiang Mingzhe Han Jiaxi Zhou Sizhou Feng Outcome of autologous stem cell transplantation in patients with favorable-risk acute myeloid leukemia in first remission Cancer Cell International Outcome Autologous stem cell transplantation Acute myeloid leukemia Favorable-risk Remission |
| title | Outcome of autologous stem cell transplantation in patients with favorable-risk acute myeloid leukemia in first remission |
| title_full | Outcome of autologous stem cell transplantation in patients with favorable-risk acute myeloid leukemia in first remission |
| title_fullStr | Outcome of autologous stem cell transplantation in patients with favorable-risk acute myeloid leukemia in first remission |
| title_full_unstemmed | Outcome of autologous stem cell transplantation in patients with favorable-risk acute myeloid leukemia in first remission |
| title_short | Outcome of autologous stem cell transplantation in patients with favorable-risk acute myeloid leukemia in first remission |
| title_sort | outcome of autologous stem cell transplantation in patients with favorable risk acute myeloid leukemia in first remission |
| topic | Outcome Autologous stem cell transplantation Acute myeloid leukemia Favorable-risk Remission |
| url | https://doi.org/10.1186/s12935-022-02750-4 |
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