Antidiarrheal Effect of Fermented Millet Bran on Diarrhea Induced by Senna Leaf in Mice
<i>Bacillus natto</i> is a kind of probiotic with various functional characteristics, which can produce a lot of nutrients during growth and reproduction. <i>Bacillus natto</i> was used as strain, the number of viable bacteria and the content of soluble dietary fiber in mille...
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MDPI AG
2022-07-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/14/2082 |
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| author | Shujun Chen Minquan Hao Lizhen Zhang |
| author_facet | Shujun Chen Minquan Hao Lizhen Zhang |
| author_sort | Shujun Chen |
| collection | DOAJ |
| description | <i>Bacillus natto</i> is a kind of probiotic with various functional characteristics, which can produce a lot of nutrients during growth and reproduction. <i>Bacillus natto</i> was used as strain, the number of viable bacteria and the content of soluble dietary fiber in millet bran were used as indexes to study the effects of inoculum size, fermentation time, and fermentation temperature on the fermentation effect, and the optimal fermentation conditions were determined by a response surface experiment. The antidiarrhea effect of fermented millet bran prepared under the best technological conditions was evaluated. The results showed that the optimum fermentation conditions were as follows: inoculum size was 7.48%, fermentation time was 47.04 h, and fermentation temperature was 36.06 °C. Under the optimal fermentation conditions, the viable bacteria count of millet bran was 8.03 log CFU/mL and the soluble dietary fiber content was 12.14%. The fermented millet bran can significantly reduce the intestinal thrust rate and serum levels of IL-6, IL-12, and TNF-α, and significantly increase the secretion of SIgA in the intestinal mucosa, which can relieve diarrhea induced by senna leaf in mice. The results of this study can provide the scientific basis for deep processing of millet bran and efficient utilization of fermented millet bran, and also provide the theoretical basis for clinical treatment of diarrhea. |
| first_indexed | 2024-03-09T11:54:56Z |
| format | Article |
| id | doaj.art-daf6a63d3a4a43e392c1e0f4056e8fa3 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T11:54:56Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-daf6a63d3a4a43e392c1e0f4056e8fa32023-11-30T23:10:51ZengMDPI AGFoods2304-81582022-07-011114208210.3390/foods11142082Antidiarrheal Effect of Fermented Millet Bran on Diarrhea Induced by Senna Leaf in MiceShujun Chen0Minquan Hao1Lizhen Zhang2College of Life Science, Shanxi University, Taiyuan 030006, ChinaCollege of Life Science, Shanxi University, Taiyuan 030006, ChinaCollege of Life Science, Shanxi University, Taiyuan 030006, China<i>Bacillus natto</i> is a kind of probiotic with various functional characteristics, which can produce a lot of nutrients during growth and reproduction. <i>Bacillus natto</i> was used as strain, the number of viable bacteria and the content of soluble dietary fiber in millet bran were used as indexes to study the effects of inoculum size, fermentation time, and fermentation temperature on the fermentation effect, and the optimal fermentation conditions were determined by a response surface experiment. The antidiarrhea effect of fermented millet bran prepared under the best technological conditions was evaluated. The results showed that the optimum fermentation conditions were as follows: inoculum size was 7.48%, fermentation time was 47.04 h, and fermentation temperature was 36.06 °C. Under the optimal fermentation conditions, the viable bacteria count of millet bran was 8.03 log CFU/mL and the soluble dietary fiber content was 12.14%. The fermented millet bran can significantly reduce the intestinal thrust rate and serum levels of IL-6, IL-12, and TNF-α, and significantly increase the secretion of SIgA in the intestinal mucosa, which can relieve diarrhea induced by senna leaf in mice. The results of this study can provide the scientific basis for deep processing of millet bran and efficient utilization of fermented millet bran, and also provide the theoretical basis for clinical treatment of diarrhea.https://www.mdpi.com/2304-8158/11/14/2082millet bran<i>Bacillus natto</i>fermentationinflammatory factorantidiarrhea |
| spellingShingle | Shujun Chen Minquan Hao Lizhen Zhang Antidiarrheal Effect of Fermented Millet Bran on Diarrhea Induced by Senna Leaf in Mice Foods millet bran <i>Bacillus natto</i> fermentation inflammatory factor antidiarrhea |
| title | Antidiarrheal Effect of Fermented Millet Bran on Diarrhea Induced by Senna Leaf in Mice |
| title_full | Antidiarrheal Effect of Fermented Millet Bran on Diarrhea Induced by Senna Leaf in Mice |
| title_fullStr | Antidiarrheal Effect of Fermented Millet Bran on Diarrhea Induced by Senna Leaf in Mice |
| title_full_unstemmed | Antidiarrheal Effect of Fermented Millet Bran on Diarrhea Induced by Senna Leaf in Mice |
| title_short | Antidiarrheal Effect of Fermented Millet Bran on Diarrhea Induced by Senna Leaf in Mice |
| title_sort | antidiarrheal effect of fermented millet bran on diarrhea induced by senna leaf in mice |
| topic | millet bran <i>Bacillus natto</i> fermentation inflammatory factor antidiarrhea |
| url | https://www.mdpi.com/2304-8158/11/14/2082 |
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