Ribosome and Translational Control in Stem Cells
Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity to self-renew while remaining poised to differentiate into multiple progenies in the context of a rapidly developing embryo or in steady-state tissues, respectively. This ability is controlled by complex genetic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/2/497 |
| _version_ | 1797706349154402304 |
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| author | Mathieu Gabut Fleur Bourdelais Sébastien Durand |
| author_facet | Mathieu Gabut Fleur Bourdelais Sébastien Durand |
| author_sort | Mathieu Gabut |
| collection | DOAJ |
| description | Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity to self-renew while remaining poised to differentiate into multiple progenies in the context of a rapidly developing embryo or in steady-state tissues, respectively. This ability is controlled by complex genetic programs, which are dynamically orchestrated at different steps of gene expression, including chromatin remodeling, mRNA transcription, processing, and stability. In addition to maintaining stem cell homeostasis, these molecular processes need to be rapidly rewired to coordinate complex physiological modifications required to redirect cell fate in response to environmental clues, such as differentiation signals or tissue injuries. Although chromatin remodeling and mRNA expression have been extensively studied in stem cells, accumulating evidence suggests that stem cell transcriptomes and proteomes are poorly correlated and that stem cell properties require finely tuned protein synthesis. In addition, many studies have shown that the biogenesis of the translation machinery, the ribosome, is decisive for sustaining ESC and ASC properties. Therefore, these observations emphasize the importance of translational control in stem cell homeostasis and fate decisions. In this review, we will provide the most recent literature describing how ribosome biogenesis and translational control regulate stem cell functions and are crucial for accommodating proteome remodeling in response to changes in stem cell fate. |
| first_indexed | 2024-03-12T05:50:56Z |
| format | Article |
| id | doaj.art-daf701db01e741e5aaa75776c538d574 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T05:50:56Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-daf701db01e741e5aaa75776c538d5742023-09-03T05:12:21ZengMDPI AGCells2073-44092020-02-019249710.3390/cells9020497cells9020497Ribosome and Translational Control in Stem CellsMathieu Gabut0Fleur Bourdelais1Sébastien Durand2Equipe ‘Transcriptome Diversity in Stem Cells’, Cancer Cell Plasticity Department, INSERM 1052, CNRS 5286, Cancer Research Center of Lyon, Centre Léon Bérard, 69008 Lyon, FranceEquipe ‘Transcriptome Diversity in Stem Cells’, Cancer Cell Plasticity Department, INSERM 1052, CNRS 5286, Cancer Research Center of Lyon, Centre Léon Bérard, 69008 Lyon, FranceEquipe ‘Transcriptome Diversity in Stem Cells’, Cancer Cell Plasticity Department, INSERM 1052, CNRS 5286, Cancer Research Center of Lyon, Centre Léon Bérard, 69008 Lyon, FranceEmbryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity to self-renew while remaining poised to differentiate into multiple progenies in the context of a rapidly developing embryo or in steady-state tissues, respectively. This ability is controlled by complex genetic programs, which are dynamically orchestrated at different steps of gene expression, including chromatin remodeling, mRNA transcription, processing, and stability. In addition to maintaining stem cell homeostasis, these molecular processes need to be rapidly rewired to coordinate complex physiological modifications required to redirect cell fate in response to environmental clues, such as differentiation signals or tissue injuries. Although chromatin remodeling and mRNA expression have been extensively studied in stem cells, accumulating evidence suggests that stem cell transcriptomes and proteomes are poorly correlated and that stem cell properties require finely tuned protein synthesis. In addition, many studies have shown that the biogenesis of the translation machinery, the ribosome, is decisive for sustaining ESC and ASC properties. Therefore, these observations emphasize the importance of translational control in stem cell homeostasis and fate decisions. In this review, we will provide the most recent literature describing how ribosome biogenesis and translational control regulate stem cell functions and are crucial for accommodating proteome remodeling in response to changes in stem cell fate.https://www.mdpi.com/2073-4409/9/2/497ribosomesstem cellstranslational regulationribosomal proteinsrrna modificationsribosome biogenesisspecialized ribosomes |
| spellingShingle | Mathieu Gabut Fleur Bourdelais Sébastien Durand Ribosome and Translational Control in Stem Cells Cells ribosomes stem cells translational regulation ribosomal proteins rrna modifications ribosome biogenesis specialized ribosomes |
| title | Ribosome and Translational Control in Stem Cells |
| title_full | Ribosome and Translational Control in Stem Cells |
| title_fullStr | Ribosome and Translational Control in Stem Cells |
| title_full_unstemmed | Ribosome and Translational Control in Stem Cells |
| title_short | Ribosome and Translational Control in Stem Cells |
| title_sort | ribosome and translational control in stem cells |
| topic | ribosomes stem cells translational regulation ribosomal proteins rrna modifications ribosome biogenesis specialized ribosomes |
| url | https://www.mdpi.com/2073-4409/9/2/497 |
| work_keys_str_mv | AT mathieugabut ribosomeandtranslationalcontrolinstemcells AT fleurbourdelais ribosomeandtranslationalcontrolinstemcells AT sebastiendurand ribosomeandtranslationalcontrolinstemcells |