Regular use of low-dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children: a Chinese national regional health center experience sharing
Abstract Background The need for pain management is increasing in pediatrics, but the side effects of overuse or abuse of analgesics can be harmful to children’s health and even life-threatening in severe cases. Methods Patients who underwent resection of Meckel’s diverticulum at the Children’s Hosp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-023-02999-7 |
| _version_ | 1797636848561946624 |
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| author | Fangyu Dai Rensen Zhang Ruyu Deng Guoyong Wang Hongjie Guo Chunbao Guo |
| author_facet | Fangyu Dai Rensen Zhang Ruyu Deng Guoyong Wang Hongjie Guo Chunbao Guo |
| author_sort | Fangyu Dai |
| collection | DOAJ |
| description | Abstract Background The need for pain management is increasing in pediatrics, but the side effects of overuse or abuse of analgesics can be harmful to children’s health and even life-threatening in severe cases. Methods Patients who underwent resection of Meckel’s diverticulum at the Children’s Hospital of Chongqing Medical University from July 1, 2019, to July 1, 2022, were included in this study. Opioids were administered through patient-controlled analgesia (PCA). Based on the preoperative choices made by the legal guardians, patients were stratified into two groups: PCA Group (PCAG) and Non-PCA Group (NPCAG). Data pertaining to the clinical characteristics and prognoses of these patients were subsequently collected and analyzed to assess the impact of opioid administration. Results In the study, a total of 126 patients were enrolled, with 72 allocated to the Patient-Controlled Analgesia Group (PCAG) and 54 to the Non-Patient-Controlled Analgesia Group (NPCAG). When compared to the NPCAG, the PCAG exhibited a longer duration of postoperative fasting (median 72 vs. 62 h, p = 0.044) and increased utilization of laxatives (12[16.7%] vs. 2[3.7%], p = 0.022). However, the PCAG also experienced higher incidences of intestinal stasis and abnormal intestinal dilation (13[18.1%] vs. 3[5.6%], p = 0.037). No statistically significant differences were observed in pain assessments at the conclusion of the surgical procedure (0 vs. 1[1.9%], p = 0.429) or within the first 24 h postoperatively (16[22.2%] vs. 18[33.3%], p = 0.164). Additionally, NPCAG patients did not necessitate increased administration of rescue analgesics (2[2.8%] vs. 4[7.4%], p = 0.432). Conclusions The administration of opioids did not demonstrably ameliorate postoperative pain but was associated with a heightened incidence of postoperative gastrointestinal tract dysfunction. The retrospective nature of the current research should be considered and should be clarified further. |
| first_indexed | 2024-03-11T12:41:09Z |
| format | Article |
| id | doaj.art-daf70dbdb4d8491fbed4e17dd5ab609c |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-11T12:41:09Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-daf70dbdb4d8491fbed4e17dd5ab609c2023-11-05T12:19:54ZengBMCBMC Gastroenterology1471-230X2023-10-012311710.1186/s12876-023-02999-7Regular use of low-dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children: a Chinese national regional health center experience sharingFangyu Dai0Rensen Zhang1Ruyu Deng2Guoyong Wang3Hongjie Guo4Chunbao Guo5Department of Pediatrics, Chongqing health center for women and childrenDepartment of Pediatrics, Chongqing health center for women and childrenDepartment of Respiratory Medicine, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical UniversityDepartment of Pediatrics, Chongqing health center for women and childrenDepartment of Anesthesiology, Children’s Hospital of Chongqing Medical UniversityAnesthesiology Class 1, Chongqing Medical UniversityAbstract Background The need for pain management is increasing in pediatrics, but the side effects of overuse or abuse of analgesics can be harmful to children’s health and even life-threatening in severe cases. Methods Patients who underwent resection of Meckel’s diverticulum at the Children’s Hospital of Chongqing Medical University from July 1, 2019, to July 1, 2022, were included in this study. Opioids were administered through patient-controlled analgesia (PCA). Based on the preoperative choices made by the legal guardians, patients were stratified into two groups: PCA Group (PCAG) and Non-PCA Group (NPCAG). Data pertaining to the clinical characteristics and prognoses of these patients were subsequently collected and analyzed to assess the impact of opioid administration. Results In the study, a total of 126 patients were enrolled, with 72 allocated to the Patient-Controlled Analgesia Group (PCAG) and 54 to the Non-Patient-Controlled Analgesia Group (NPCAG). When compared to the NPCAG, the PCAG exhibited a longer duration of postoperative fasting (median 72 vs. 62 h, p = 0.044) and increased utilization of laxatives (12[16.7%] vs. 2[3.7%], p = 0.022). However, the PCAG also experienced higher incidences of intestinal stasis and abnormal intestinal dilation (13[18.1%] vs. 3[5.6%], p = 0.037). No statistically significant differences were observed in pain assessments at the conclusion of the surgical procedure (0 vs. 1[1.9%], p = 0.429) or within the first 24 h postoperatively (16[22.2%] vs. 18[33.3%], p = 0.164). Additionally, NPCAG patients did not necessitate increased administration of rescue analgesics (2[2.8%] vs. 4[7.4%], p = 0.432). Conclusions The administration of opioids did not demonstrably ameliorate postoperative pain but was associated with a heightened incidence of postoperative gastrointestinal tract dysfunction. The retrospective nature of the current research should be considered and should be clarified further.https://doi.org/10.1186/s12876-023-02999-7Postoperative painPostoperative gastrointestinal tract dysfunctionEnhanced recovery after SurgeryPatient-controlled analgesiaPediatricsMeckel’s diverticulum |
| spellingShingle | Fangyu Dai Rensen Zhang Ruyu Deng Guoyong Wang Hongjie Guo Chunbao Guo Regular use of low-dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children: a Chinese national regional health center experience sharing BMC Gastroenterology Postoperative pain Postoperative gastrointestinal tract dysfunction Enhanced recovery after Surgery Patient-controlled analgesia Pediatrics Meckel’s diverticulum |
| title | Regular use of low-dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children: a Chinese national regional health center experience sharing |
| title_full | Regular use of low-dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children: a Chinese national regional health center experience sharing |
| title_fullStr | Regular use of low-dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children: a Chinese national regional health center experience sharing |
| title_full_unstemmed | Regular use of low-dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children: a Chinese national regional health center experience sharing |
| title_short | Regular use of low-dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children: a Chinese national regional health center experience sharing |
| title_sort | regular use of low dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children a chinese national regional health center experience sharing |
| topic | Postoperative pain Postoperative gastrointestinal tract dysfunction Enhanced recovery after Surgery Patient-controlled analgesia Pediatrics Meckel’s diverticulum |
| url | https://doi.org/10.1186/s12876-023-02999-7 |
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