Development of delayed thyroid stimulating hormone elevation in small-for-gestational-age infants: is a second screening needed?
Purpose Recent reports indicate that small for gestational age (SGA) could be a risk factor for delayed thyroid stimulating hormone (dTSH) elevation in preterm infants. The development of dTSH elevation in SGA late-preterm infants with a gestational age of 34–36 weeks has been investigated in only a...
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Korean Society of Pediatric Endocrinology
2022-06-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
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| Online Access: | http://e-apem.org/upload/pdf/apem-2244002-001.pdf |
| _version_ | 1827973063278329856 |
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| author | Gahyun Lee So Yun Park Jae Hyun Park Seokjin Kang |
| author_facet | Gahyun Lee So Yun Park Jae Hyun Park Seokjin Kang |
| author_sort | Gahyun Lee |
| collection | DOAJ |
| description | Purpose Recent reports indicate that small for gestational age (SGA) could be a risk factor for delayed thyroid stimulating hormone (dTSH) elevation in preterm infants. The development of dTSH elevation in SGA late-preterm infants with a gestational age of 34–36 weeks has been investigated in only a few studies. Methods In the present retrospective study, 70 SGA infants and 86 sex- and gestational age-matched controls who presented with normal results on initial thyroid function testing were included. Results SGA infants had a significantly higher prevalence of dTSH elevation (15.7% vs. 3.5%, P=0.009) compared with appropriate-for-gestational age infants. In SGA infants, the mean age at the time of dTSH was 24 days. Development of dTSH was associated with SGA and medical treatment with dopamine or furosemide. After adjusting for confounding factors, multiple logistic regression analysis showed SGA was a significant risk factor for the development of dTSH elevation (odds ratio, 23.2; 95% confidence interval, 2.27–236.91; P=0.008). Conclusions SGA infants may be at risk for dTSH and clinicians could consider a second thyroid screening test around the age of 1 month. |
| first_indexed | 2024-04-09T19:30:25Z |
| format | Article |
| id | doaj.art-dafab0fc0a9e4dfdaaa03a36b783bb0c |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-04-09T19:30:25Z |
| publishDate | 2022-06-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-dafab0fc0a9e4dfdaaa03a36b783bb0c2023-04-05T00:54:29ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922022-06-01281424810.6065/apem.2244002.001942Development of delayed thyroid stimulating hormone elevation in small-for-gestational-age infants: is a second screening needed?Gahyun Lee0So Yun Park1Jae Hyun Park2Seokjin Kang3 Department of Pediatrics, Keimyung University Dongsan Hospital, Daegu, Korea Department of Pediatrics, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea, Daegu, Korea Department of Pediatrics, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea, Daegu, Korea Department of Pediatrics, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea, Daegu, KoreaPurpose Recent reports indicate that small for gestational age (SGA) could be a risk factor for delayed thyroid stimulating hormone (dTSH) elevation in preterm infants. The development of dTSH elevation in SGA late-preterm infants with a gestational age of 34–36 weeks has been investigated in only a few studies. Methods In the present retrospective study, 70 SGA infants and 86 sex- and gestational age-matched controls who presented with normal results on initial thyroid function testing were included. Results SGA infants had a significantly higher prevalence of dTSH elevation (15.7% vs. 3.5%, P=0.009) compared with appropriate-for-gestational age infants. In SGA infants, the mean age at the time of dTSH was 24 days. Development of dTSH was associated with SGA and medical treatment with dopamine or furosemide. After adjusting for confounding factors, multiple logistic regression analysis showed SGA was a significant risk factor for the development of dTSH elevation (odds ratio, 23.2; 95% confidence interval, 2.27–236.91; P=0.008). Conclusions SGA infants may be at risk for dTSH and clinicians could consider a second thyroid screening test around the age of 1 month.http://e-apem.org/upload/pdf/apem-2244002-001.pdfcongenital hypothyroidismdelayed thyrotropin elevationlevothy roxinenewborn thyroid screeningsmall for gestational age |
| spellingShingle | Gahyun Lee So Yun Park Jae Hyun Park Seokjin Kang Development of delayed thyroid stimulating hormone elevation in small-for-gestational-age infants: is a second screening needed? Annals of Pediatric Endocrinology & Metabolism congenital hypothyroidism delayed thyrotropin elevation levothy roxine newborn thyroid screening small for gestational age |
| title | Development of delayed thyroid stimulating hormone elevation in small-for-gestational-age infants: is a second screening needed? |
| title_full | Development of delayed thyroid stimulating hormone elevation in small-for-gestational-age infants: is a second screening needed? |
| title_fullStr | Development of delayed thyroid stimulating hormone elevation in small-for-gestational-age infants: is a second screening needed? |
| title_full_unstemmed | Development of delayed thyroid stimulating hormone elevation in small-for-gestational-age infants: is a second screening needed? |
| title_short | Development of delayed thyroid stimulating hormone elevation in small-for-gestational-age infants: is a second screening needed? |
| title_sort | development of delayed thyroid stimulating hormone elevation in small for gestational age infants is a second screening needed |
| topic | congenital hypothyroidism delayed thyrotropin elevation levothy roxine newborn thyroid screening small for gestational age |
| url | http://e-apem.org/upload/pdf/apem-2244002-001.pdf |
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