Review of Antiviral Effects of Glycyrrhiza glabra L. and Its Active Component, Glycyrrhizin
Background: Licorice (Glycyrrhiza sp.) belongs to family of Leguminosae. A number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoides, chalcones and various other substances. Glycyrrhizic acid is the main biologically active component of it. Obje...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Institue of Medicinal Plants, ACECR
2007-05-01
|
| Series: | Journal of Medicinal Plants |
| Subjects: | |
| Online Access: | http://jmp.ir/article-1-609-en.html |
| _version_ | 1819101634862514176 |
|---|---|
| author | M Nassiri Asl H Hosseinzadeh |
| author_facet | M Nassiri Asl H Hosseinzadeh |
| author_sort | M Nassiri Asl |
| collection | DOAJ |
| description | Background: Licorice (Glycyrrhiza sp.) belongs to family of Leguminosae. A number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoides, chalcones and various other substances. Glycyrrhizic acid is the main biologically active component of it. Objective: The aim of this review is to provide an updated overview of experimental investigations focused on the antivirus effects of Glycyrrhiza and its active component, glycyrrhizin. Methods: A computerized search of published articles was performed using the electronic database such as MEDLINE from 1980 to 2005. Results: Glycyrrhiza exerts antiviral activity toward a number of viruses, including hepatitis A, B, C, varicella zoster, HIV, herpes simplex type-1, SARS, cytomegalo virus. Now glycyrrhizic acid has been used for the treatment of the patients with chronic active hepatitis and about the mechanism of glycyrrhizin’s activity against other viruses, it seems that glycyrrhizin inhibits replication, affects cellular signaling pathways, upregulate expression of inducible nitrous oxide synthase and production of nitrous oxide in macrophages. Conclusion: Thus, it seems that future clinical research is needed to define the possible use of licorice and it active component, glycyrrhizic acid as effective antivirus agents for treatment other viral infections. |
| first_indexed | 2024-12-22T01:21:48Z |
| format | Article |
| id | doaj.art-dafb80ca5b9c4d5aba80e50dd18c2578 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-22T01:21:48Z |
| publishDate | 2007-05-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-dafb80ca5b9c4d5aba80e50dd18c25782022-12-21T18:43:42ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582007-05-01622112Review of Antiviral Effects of Glycyrrhiza glabra L. and Its Active Component, GlycyrrhizinM Nassiri Asl0H Hosseinzadeh1 Department of Pharmacology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Department of Pharmacology and Toxicology, Pharmaceutical Research center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Background: Licorice (Glycyrrhiza sp.) belongs to family of Leguminosae. A number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoides, chalcones and various other substances. Glycyrrhizic acid is the main biologically active component of it. Objective: The aim of this review is to provide an updated overview of experimental investigations focused on the antivirus effects of Glycyrrhiza and its active component, glycyrrhizin. Methods: A computerized search of published articles was performed using the electronic database such as MEDLINE from 1980 to 2005. Results: Glycyrrhiza exerts antiviral activity toward a number of viruses, including hepatitis A, B, C, varicella zoster, HIV, herpes simplex type-1, SARS, cytomegalo virus. Now glycyrrhizic acid has been used for the treatment of the patients with chronic active hepatitis and about the mechanism of glycyrrhizin’s activity against other viruses, it seems that glycyrrhizin inhibits replication, affects cellular signaling pathways, upregulate expression of inducible nitrous oxide synthase and production of nitrous oxide in macrophages. Conclusion: Thus, it seems that future clinical research is needed to define the possible use of licorice and it active component, glycyrrhizic acid as effective antivirus agents for treatment other viral infections.http://jmp.ir/article-1-609-en.htmllicoriceglycyrrhizic acidhcvcmvantiviral |
| spellingShingle | M Nassiri Asl H Hosseinzadeh Review of Antiviral Effects of Glycyrrhiza glabra L. and Its Active Component, Glycyrrhizin Journal of Medicinal Plants licorice glycyrrhizic acid hcv cmv antiviral |
| title | Review of Antiviral Effects of Glycyrrhiza glabra L. and Its Active Component, Glycyrrhizin |
| title_full | Review of Antiviral Effects of Glycyrrhiza glabra L. and Its Active Component, Glycyrrhizin |
| title_fullStr | Review of Antiviral Effects of Glycyrrhiza glabra L. and Its Active Component, Glycyrrhizin |
| title_full_unstemmed | Review of Antiviral Effects of Glycyrrhiza glabra L. and Its Active Component, Glycyrrhizin |
| title_short | Review of Antiviral Effects of Glycyrrhiza glabra L. and Its Active Component, Glycyrrhizin |
| title_sort | review of antiviral effects of glycyrrhiza glabra l and its active component glycyrrhizin |
| topic | licorice glycyrrhizic acid hcv cmv antiviral |
| url | http://jmp.ir/article-1-609-en.html |
| work_keys_str_mv | AT mnassiriasl reviewofantiviraleffectsofglycyrrhizaglabralanditsactivecomponentglycyrrhizin AT hhosseinzadeh reviewofantiviraleffectsofglycyrrhizaglabralanditsactivecomponentglycyrrhizin |