Biological and Pathological Implications of an Alternative ATP-Powered Proteasomal Assembly With Cdc48 and the 20S Peptidase

Biological and Pathological Implications of an Alternative ATP-Powered Proteasomal Assembly With Cdc48 and the 20S Peptidase

The ATP-powered protein degradation machinery plays essential roles in maintaining protein homeostasis in all organisms. Robust proteolytic activities are typically sequestered within protein complexes to avoid the fatal removal of essential proteins. Because the openings of proteolytic chambers are...

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Bibliographic Details
Main Authors: Masatoshi Esaki, Ai Johjima-Murata, Md. Tanvir Islam, Teru Ogura
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
AAA ATPase
Cdc48/p97/VCP
proteasome
proteolysis
Sod1
ALS
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2018.00056/full

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