In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives
Essential oil of Elettaria cardamomum (Green cardamom) is effective in the treatment of various disease conditions. Globally, Guatemala is the leading producer of green cardamom fruits. Green-cardamom fruits from Guatemala were purchased from a Saudi Arabian market. The Guatemala cardamom essential...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Journal of Taibah University for Science |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/16583655.2021.2002550 |
| _version_ | 1818323629319913472 |
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| author | Aftab Alam Talha jawaid Pravej Alam |
| author_facet | Aftab Alam Talha jawaid Pravej Alam |
| author_sort | Aftab Alam |
| collection | DOAJ |
| description | Essential oil of Elettaria cardamomum (Green cardamom) is effective in the treatment of various disease conditions. Globally, Guatemala is the leading producer of green cardamom fruits. Green-cardamom fruits from Guatemala were purchased from a Saudi Arabian market. The Guatemala cardamom essential oil (GCEO) was extracted using hydro-distillation method, and analyzed using gaschromatography/ mass-spectrometry (GC-MS). The antioxidant and anti-inflammatory activities were studied using 2,2-diphenyl-1-picrylhydrazyl-hydrate, ferric-chloride, bovine serum-albumin and proteinase inhibitory assays. GC-MS results confirmed the presence of α- terpinyl acetate and 1,8-cineole as major components. The antioxidant and anti-inflammatory activities of GCEO were found to be significant compared with those of standard ascorbic acid and ibuprofen, respectively. The molecular-docking study revealed the considerable binding potential of α-terpinyl acetate and 1,8-cineole with human-peroxiredoxin-5, tyrosine-kinases and Human-5-LOX receptors. The in-silico activity prediction analysis confirmed the antioxidant and anti-inflammatory potential, whereas the pharmacokinetics confirmed the safety of most of the GCEO compounds. |
| first_indexed | 2024-12-13T11:15:44Z |
| format | Article |
| id | doaj.art-dafcc86791134851a6bf56e8a55a29ba |
| institution | Directory Open Access Journal |
| issn | 1658-3655 |
| language | English |
| last_indexed | 2024-12-13T11:15:44Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Taibah University for Science |
| spelling | doaj.art-dafcc86791134851a6bf56e8a55a29ba2022-12-21T23:48:37ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552021-01-0115175776810.1080/16583655.2021.20025502002550In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactivesAftab Alam0Talha jawaid1Pravej Alam2College of Pharmacy, Prince Sattam Bin Abdulaziz UniversityCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU)College of Science and Humanities, Prince Sattam Bin Abdulaziz UniversityEssential oil of Elettaria cardamomum (Green cardamom) is effective in the treatment of various disease conditions. Globally, Guatemala is the leading producer of green cardamom fruits. Green-cardamom fruits from Guatemala were purchased from a Saudi Arabian market. The Guatemala cardamom essential oil (GCEO) was extracted using hydro-distillation method, and analyzed using gaschromatography/ mass-spectrometry (GC-MS). The antioxidant and anti-inflammatory activities were studied using 2,2-diphenyl-1-picrylhydrazyl-hydrate, ferric-chloride, bovine serum-albumin and proteinase inhibitory assays. GC-MS results confirmed the presence of α- terpinyl acetate and 1,8-cineole as major components. The antioxidant and anti-inflammatory activities of GCEO were found to be significant compared with those of standard ascorbic acid and ibuprofen, respectively. The molecular-docking study revealed the considerable binding potential of α-terpinyl acetate and 1,8-cineole with human-peroxiredoxin-5, tyrosine-kinases and Human-5-LOX receptors. The in-silico activity prediction analysis confirmed the antioxidant and anti-inflammatory potential, whereas the pharmacokinetics confirmed the safety of most of the GCEO compounds.http://dx.doi.org/10.1080/16583655.2021.2002550guatemala cardamomessential oilchemical compositionantioxidantanti-inflammatoryin silico study |
| spellingShingle | Aftab Alam Talha jawaid Pravej Alam In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives Journal of Taibah University for Science guatemala cardamom essential oil chemical composition antioxidant anti-inflammatory in silico study |
| title | In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives |
| title_full | In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives |
| title_fullStr | In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives |
| title_full_unstemmed | In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives |
| title_short | In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives |
| title_sort | in vitro antioxidant and anti inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives |
| topic | guatemala cardamom essential oil chemical composition antioxidant anti-inflammatory in silico study |
| url | http://dx.doi.org/10.1080/16583655.2021.2002550 |
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