Effects of compound organic acid calcium on growth performance, hepatic antioxidation and intestinal barrier of male broilers under heat stress
Objective The aim of this study was to evaluate the effects of compound organic acid calcium (COAC) on growth performance, hepatic antioxidant status and intestinal barrier of male broilers under high ambient temperature (32.7°C). Methods Nine hundred healthy one-d-old Cobb-500 male broiler chicks w...
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| Format: | Article |
| Language: | English |
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Asian-Australasian Association of Animal Production Societies
2020-07-01
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| Series: | Asian-Australasian Journal of Animal Sciences |
| Subjects: | |
| Online Access: | http://www.ajas.info/upload/pdf/ajas-19-0274.pdf |
| _version_ | 1811335525727993856 |
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| author | Junna He Lianxiang Ma Jialing Qiu Xintao Lu Chuanchuan Hou Bing Liu Dongyou Yu |
| author_facet | Junna He Lianxiang Ma Jialing Qiu Xintao Lu Chuanchuan Hou Bing Liu Dongyou Yu |
| author_sort | Junna He |
| collection | DOAJ |
| description | Objective The aim of this study was to evaluate the effects of compound organic acid calcium (COAC) on growth performance, hepatic antioxidant status and intestinal barrier of male broilers under high ambient temperature (32.7°C). Methods Nine hundred healthy one-d-old Cobb-500 male broiler chicks were randomly assigned into three groups with six replicates of 50 birds each. A basal diet supplemented with 0% (control), 0.4% and 0.8% COAC, respectively were fed to birds for 6 weeks. All treatments were under high ambient indoor temperature of 32.7°C, and had a constant calcium and available phosphorus ratio. Results The results showed that, compared with control, the average daily gain of broilers in 0.4% and 0.8% was significantly increased and the ratio of feed to gain in in 0.4% and 0.8% was significantly decreased at 1 to 21, 22 to 42 and 1 to 42 days of age (p<0.05). Compared with control, 0.8% COAC slightly decreased (p = 0.093) the content of malondialdehyde in liver at 42 days of age while 0.4% COAC significantly decreased (p<0.05) the activity of alkaline phosphatase. Furthermore, 0.4% COAC significantly enhanced the intestinal barrier function via increasing jejunal and ileal ocln transcription, promoting jejunal mucin 2 transcription at 42 days of age (p<0.05), and decreasing jejunal toll-like receptor 2 (TLR-2) and ileal TLR-15, inducible nitric oxide synthase compared with control group (p<0.05). Whereas, no significant differences on the transcription of interleukin-1β in jejunum and ileum were observed among three treatments (p>0.05). Overall, heat stress caused by high natural environment temperature may induce the damage to hepatic antioxidation and intestinal barrier. Conclusion Dietary inclusion of COAC can improve the tolerance of broilers to thermal environment through the modification of antioxidative parameters in liver and the mRNA expression of genes in intestinal barrier, resulting in an optimal inclusion level of 0.4%. |
| first_indexed | 2024-04-13T17:25:22Z |
| format | Article |
| id | doaj.art-dafd5b0486d140629ffbdffde2ce390e |
| institution | Directory Open Access Journal |
| issn | 1011-2367 1976-5517 |
| language | English |
| last_indexed | 2024-04-13T17:25:22Z |
| publishDate | 2020-07-01 |
| publisher | Asian-Australasian Association of Animal Production Societies |
| record_format | Article |
| series | Asian-Australasian Journal of Animal Sciences |
| spelling | doaj.art-dafd5b0486d140629ffbdffde2ce390e2022-12-22T02:37:48ZengAsian-Australasian Association of Animal Production SocietiesAsian-Australasian Journal of Animal Sciences1011-23671976-55172020-07-013371156116610.5713/ajas.19.027424364Effects of compound organic acid calcium on growth performance, hepatic antioxidation and intestinal barrier of male broilers under heat stressJunna He0Lianxiang Ma1Jialing Qiu2Xintao Lu3Chuanchuan Hou4Bing Liu5Dongyou Yu6 College of Animal Science, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, China College of Animal Science, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, China College of Animal Science, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, China College of Animal Science, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, China College of Animal Science, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, China College of Animal Science, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, China College of Animal Science, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, ChinaObjective The aim of this study was to evaluate the effects of compound organic acid calcium (COAC) on growth performance, hepatic antioxidant status and intestinal barrier of male broilers under high ambient temperature (32.7°C). Methods Nine hundred healthy one-d-old Cobb-500 male broiler chicks were randomly assigned into three groups with six replicates of 50 birds each. A basal diet supplemented with 0% (control), 0.4% and 0.8% COAC, respectively were fed to birds for 6 weeks. All treatments were under high ambient indoor temperature of 32.7°C, and had a constant calcium and available phosphorus ratio. Results The results showed that, compared with control, the average daily gain of broilers in 0.4% and 0.8% was significantly increased and the ratio of feed to gain in in 0.4% and 0.8% was significantly decreased at 1 to 21, 22 to 42 and 1 to 42 days of age (p<0.05). Compared with control, 0.8% COAC slightly decreased (p = 0.093) the content of malondialdehyde in liver at 42 days of age while 0.4% COAC significantly decreased (p<0.05) the activity of alkaline phosphatase. Furthermore, 0.4% COAC significantly enhanced the intestinal barrier function via increasing jejunal and ileal ocln transcription, promoting jejunal mucin 2 transcription at 42 days of age (p<0.05), and decreasing jejunal toll-like receptor 2 (TLR-2) and ileal TLR-15, inducible nitric oxide synthase compared with control group (p<0.05). Whereas, no significant differences on the transcription of interleukin-1β in jejunum and ileum were observed among three treatments (p>0.05). Overall, heat stress caused by high natural environment temperature may induce the damage to hepatic antioxidation and intestinal barrier. Conclusion Dietary inclusion of COAC can improve the tolerance of broilers to thermal environment through the modification of antioxidative parameters in liver and the mRNA expression of genes in intestinal barrier, resulting in an optimal inclusion level of 0.4%.http://www.ajas.info/upload/pdf/ajas-19-0274.pdfgrowth performancecompound organic acid calciumantioxidationintestinal barrierheat stressbroiler |
| spellingShingle | Junna He Lianxiang Ma Jialing Qiu Xintao Lu Chuanchuan Hou Bing Liu Dongyou Yu Effects of compound organic acid calcium on growth performance, hepatic antioxidation and intestinal barrier of male broilers under heat stress Asian-Australasian Journal of Animal Sciences growth performance compound organic acid calcium antioxidation intestinal barrier heat stress broiler |
| title | Effects of compound organic acid calcium on growth performance, hepatic antioxidation and intestinal barrier of male broilers under heat stress |
| title_full | Effects of compound organic acid calcium on growth performance, hepatic antioxidation and intestinal barrier of male broilers under heat stress |
| title_fullStr | Effects of compound organic acid calcium on growth performance, hepatic antioxidation and intestinal barrier of male broilers under heat stress |
| title_full_unstemmed | Effects of compound organic acid calcium on growth performance, hepatic antioxidation and intestinal barrier of male broilers under heat stress |
| title_short | Effects of compound organic acid calcium on growth performance, hepatic antioxidation and intestinal barrier of male broilers under heat stress |
| title_sort | effects of compound organic acid calcium on growth performance hepatic antioxidation and intestinal barrier of male broilers under heat stress |
| topic | growth performance compound organic acid calcium antioxidation intestinal barrier heat stress broiler |
| url | http://www.ajas.info/upload/pdf/ajas-19-0274.pdf |
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