Significance of eosinophils in diagnosing Hashimoto′s thyroiditis on fine-needle aspiration cytology
<b>Background:</b> Hashimoto′s thyroiditis (HT) is the most common cause of hypothyroidism in those areas of the world where iodine levels are sufficient. Fine-needle aspiration cytology (FNAC) can accurately diagnose this lesion in most of the patients. However, a small perce...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-07-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=3;spage=476;epage=479;aulast=Ekambaram |
| _version_ | 1818596214316204032 |
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| author | Ekambaram Maheswari Kumar Bipin Chowdhary Nitlotpal Siddaraju N Kumar Surendra |
| author_facet | Ekambaram Maheswari Kumar Bipin Chowdhary Nitlotpal Siddaraju N Kumar Surendra |
| author_sort | Ekambaram Maheswari |
| collection | DOAJ |
| description | <b>Background:</b> Hashimoto′s thyroiditis (HT) is the most common cause of hypothyroidism in those areas of the world where iodine levels are sufficient. Fine-needle aspiration cytology (FNAC) can accurately diagnose this lesion in most of the patients. However, a small percentage of cases may be missed due to inherent limitations of this procedure. Therefore, cytologic clues to increase sensitivity of diagnosis need to be searched for. <b>Aims:</b> To assess whether an eosinophilic infiltration of the thyroid gland has a higher association with HT than colloid goiter. <b>Materials and Methods:</b> The study was a case-control study. Smears obtained by FNAC of 50 case, each of HT (which served as cases) and colloid goiter (which served as controls) were observed. The number of eosinophils and neutrophils per high-power field (HPF) was counted in all the smears. The eosinophil-neutrophil ratio in the smears, diagnosed as HT, was then compared with that of colloid goiter using unpaired <i>t</i>-test. <b>Results:</b> Smears diagnosed as HT was found to have a significantly higher eosinophil-neutrophil ratio than smears diagnosed as colloid goiter (<i>P</i> value 0.0001). <b>Conclusion:</b> Eosinophilic infiltration of the thyroid gland has higher association with Hashimoto thyroiditis. |
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| format | Article |
| id | doaj.art-dafe4aeb541e4498a0bf88c41369d1e5 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 0974-5130 |
| language | English |
| last_indexed | 2024-12-16T11:28:21Z |
| publishDate | 2010-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-dafe4aeb541e4498a0bf88c41369d1e52022-12-21T22:33:18ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302010-07-01533476479Significance of eosinophils in diagnosing Hashimoto′s thyroiditis on fine-needle aspiration cytologyEkambaram MaheswariKumar BipinChowdhary NitlotpalSiddaraju NKumar Surendra<b>Background:</b> Hashimoto′s thyroiditis (HT) is the most common cause of hypothyroidism in those areas of the world where iodine levels are sufficient. Fine-needle aspiration cytology (FNAC) can accurately diagnose this lesion in most of the patients. However, a small percentage of cases may be missed due to inherent limitations of this procedure. Therefore, cytologic clues to increase sensitivity of diagnosis need to be searched for. <b>Aims:</b> To assess whether an eosinophilic infiltration of the thyroid gland has a higher association with HT than colloid goiter. <b>Materials and Methods:</b> The study was a case-control study. Smears obtained by FNAC of 50 case, each of HT (which served as cases) and colloid goiter (which served as controls) were observed. The number of eosinophils and neutrophils per high-power field (HPF) was counted in all the smears. The eosinophil-neutrophil ratio in the smears, diagnosed as HT, was then compared with that of colloid goiter using unpaired <i>t</i>-test. <b>Results:</b> Smears diagnosed as HT was found to have a significantly higher eosinophil-neutrophil ratio than smears diagnosed as colloid goiter (<i>P</i> value 0.0001). <b>Conclusion:</b> Eosinophilic infiltration of the thyroid gland has higher association with Hashimoto thyroiditis.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=3;spage=476;epage=479;aulast=EkambaramEosinophilsHashimoto′s thyroiditisfine-needle aspiration cytology |
| spellingShingle | Ekambaram Maheswari Kumar Bipin Chowdhary Nitlotpal Siddaraju N Kumar Surendra Significance of eosinophils in diagnosing Hashimoto′s thyroiditis on fine-needle aspiration cytology Indian Journal of Pathology and Microbiology Eosinophils Hashimoto′s thyroiditis fine-needle aspiration cytology |
| title | Significance of eosinophils in diagnosing Hashimoto′s thyroiditis on fine-needle aspiration cytology |
| title_full | Significance of eosinophils in diagnosing Hashimoto′s thyroiditis on fine-needle aspiration cytology |
| title_fullStr | Significance of eosinophils in diagnosing Hashimoto′s thyroiditis on fine-needle aspiration cytology |
| title_full_unstemmed | Significance of eosinophils in diagnosing Hashimoto′s thyroiditis on fine-needle aspiration cytology |
| title_short | Significance of eosinophils in diagnosing Hashimoto′s thyroiditis on fine-needle aspiration cytology |
| title_sort | significance of eosinophils in diagnosing hashimoto x2032 s thyroiditis on fine needle aspiration cytology |
| topic | Eosinophils Hashimoto′s thyroiditis fine-needle aspiration cytology |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=3;spage=476;epage=479;aulast=Ekambaram |
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