Systematic review and meta-analysis of environmental toxic metal contaminants and the risk of ischemic stroke
Background: Stroke is the second largest cause of mortality (WHO 2014) and long-lasting disability worldwide. Many risk factors are associated with stroke, such as age, gender, chronic illnesses, cardiovascular disease, lifestyle, and smoking. With global industrialization, the roles of environmenta...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=6;spage=1159;epage=1166;aulast=Dev |
| _version_ | 1811295440509861888 |
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| author | Priya Dev Priya Gupta Archisman Mahapatra Mareena Cyriac Amit Kumar Varun Kumar Singh Vijaya Nath Mishra Abhishek Pathak |
| author_facet | Priya Dev Priya Gupta Archisman Mahapatra Mareena Cyriac Amit Kumar Varun Kumar Singh Vijaya Nath Mishra Abhishek Pathak |
| author_sort | Priya Dev |
| collection | DOAJ |
| description | Background: Stroke is the second largest cause of mortality (WHO 2014) and long-lasting disability worldwide. Many risk factors are associated with stroke, such as age, gender, chronic illnesses, cardiovascular disease, lifestyle, and smoking. With global industrialization, the roles of environmental contaminants and their association with stroke are still unclear and have attracted much more attention. Materials and Methods: We conducted a systematic review on the environmental toxic metal contaminants and the risk of ischemic stroke. A comprehensive literature search was carried out till June 30, 2021 from databases such as PubMed, Science Direct, Embase, and Scopus. The quality of all the articles which met our inclusion criteria was assessed using Newcastle–Ottawa scaling, and four eligible studies were included for our systematic review. Results: The serum and urine cadmium concentrations were positively associated with the risk of ischemic stroke. There was an inverse association of serum and urine concentrations of mercury (Hg), serum concentration of gold and cerium with ischemic stroke, and the serum and urine concentrations of lead (Pb) had no association with ischemic stroke risk. Conclusion: The study showed strong associations between heavy metals and ischemic stroke, but more studies are required to prove the associations. |
| first_indexed | 2024-04-13T05:32:32Z |
| format | Article |
| id | doaj.art-dafec2e8382346ec979a272ade662708 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-04-13T05:32:32Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-dafec2e8382346ec979a272ade6627082022-12-22T03:00:23ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492022-01-012561159116610.4103/aian.aian_530_22Systematic review and meta-analysis of environmental toxic metal contaminants and the risk of ischemic strokePriya DevPriya GuptaArchisman MahapatraMareena CyriacAmit KumarVarun Kumar SinghVijaya Nath MishraAbhishek PathakBackground: Stroke is the second largest cause of mortality (WHO 2014) and long-lasting disability worldwide. Many risk factors are associated with stroke, such as age, gender, chronic illnesses, cardiovascular disease, lifestyle, and smoking. With global industrialization, the roles of environmental contaminants and their association with stroke are still unclear and have attracted much more attention. Materials and Methods: We conducted a systematic review on the environmental toxic metal contaminants and the risk of ischemic stroke. A comprehensive literature search was carried out till June 30, 2021 from databases such as PubMed, Science Direct, Embase, and Scopus. The quality of all the articles which met our inclusion criteria was assessed using Newcastle–Ottawa scaling, and four eligible studies were included for our systematic review. Results: The serum and urine cadmium concentrations were positively associated with the risk of ischemic stroke. There was an inverse association of serum and urine concentrations of mercury (Hg), serum concentration of gold and cerium with ischemic stroke, and the serum and urine concentrations of lead (Pb) had no association with ischemic stroke risk. Conclusion: The study showed strong associations between heavy metals and ischemic stroke, but more studies are required to prove the associations.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=6;spage=1159;epage=1166;aulast=Devheavy metalsischemic strokemeta-analysismetal contaminantsstrokesystematic review |
| spellingShingle | Priya Dev Priya Gupta Archisman Mahapatra Mareena Cyriac Amit Kumar Varun Kumar Singh Vijaya Nath Mishra Abhishek Pathak Systematic review and meta-analysis of environmental toxic metal contaminants and the risk of ischemic stroke Annals of Indian Academy of Neurology heavy metals ischemic stroke meta-analysis metal contaminants stroke systematic review |
| title | Systematic review and meta-analysis of environmental toxic metal contaminants and the risk of ischemic stroke |
| title_full | Systematic review and meta-analysis of environmental toxic metal contaminants and the risk of ischemic stroke |
| title_fullStr | Systematic review and meta-analysis of environmental toxic metal contaminants and the risk of ischemic stroke |
| title_full_unstemmed | Systematic review and meta-analysis of environmental toxic metal contaminants and the risk of ischemic stroke |
| title_short | Systematic review and meta-analysis of environmental toxic metal contaminants and the risk of ischemic stroke |
| title_sort | systematic review and meta analysis of environmental toxic metal contaminants and the risk of ischemic stroke |
| topic | heavy metals ischemic stroke meta-analysis metal contaminants stroke systematic review |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=6;spage=1159;epage=1166;aulast=Dev |
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