Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1
By adding l-tryptophan and l-phenylalanine to GPY medium, twenty-eight compounds, including amides, polyketides, a sesquiterpenoid, a diterpenoid, a meroterpenoid, diketopiperazines, β-carbolines, fumiquinazolines, and indole alkaloids, were discovered from the marine-derived fungus Dichotomomyces c...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-11-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/15/11/339 |
| _version_ | 1828282736497917952 |
|---|---|
| author | Yan-Xiu Chen Meng-Yang Xu Hou-Jin Li Kun-Jiao Zeng Wen-Zhe Ma Guo-Bao Tian Jun Xu De-Po Yang Wen-Jian Lan |
| author_facet | Yan-Xiu Chen Meng-Yang Xu Hou-Jin Li Kun-Jiao Zeng Wen-Zhe Ma Guo-Bao Tian Jun Xu De-Po Yang Wen-Jian Lan |
| author_sort | Yan-Xiu Chen |
| collection | DOAJ |
| description | By adding l-tryptophan and l-phenylalanine to GPY medium, twenty-eight compounds, including amides, polyketides, a sesquiterpenoid, a diterpenoid, a meroterpenoid, diketopiperazines, β-carbolines, fumiquinazolines, and indole alkaloids, were discovered from the marine-derived fungus Dichotomomyces cejpii F31-1, demonstrating the tremendous biosynthetic potential of this fungal strain. Among these compounds, four amides dichotomocejs A–D (1–4), one polyketide dichocetide A (5), and two diketopiperazines dichocerazines A–B (15 and 16) are new. The structures of these new compounds were determined by interpreting detailed spectroscopic data as well as calculating optical rotation values and ECD spectra. Obviously, Dichotomomyces cejpii can effectively use an amino acid-directed strategy to enhance the production of nitrogen-containing compounds. Dichotomocej A (1) displayed moderate cytotoxicity against the human rhabdomyosarcoma cell line RD with an IC50 value of 39.1 µM, and pityriacitrin (22) showed moderate cytotoxicity against the human colon carcinoma cell line HCT116 with an IC50 value of 35.1 µM. |
| first_indexed | 2024-04-13T08:35:00Z |
| format | Article |
| id | doaj.art-daff0c05238b4f35981caff2b7b567da |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T08:35:00Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-daff0c05238b4f35981caff2b7b567da2022-12-22T02:54:09ZengMDPI AGMarine Drugs1660-33972017-11-01151133910.3390/md15110339md15110339Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1Yan-Xiu Chen0Meng-Yang Xu1Hou-Jin Li2Kun-Jiao Zeng3Wen-Zhe Ma4Guo-Bao Tian5Jun Xu6De-Po Yang7Wen-Jian Lan8School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Chemistry, Sun Yat-sen University, Guangzhou 510275, ChinaZhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa 519020, Macau (SAR), ChinaZhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaBy adding l-tryptophan and l-phenylalanine to GPY medium, twenty-eight compounds, including amides, polyketides, a sesquiterpenoid, a diterpenoid, a meroterpenoid, diketopiperazines, β-carbolines, fumiquinazolines, and indole alkaloids, were discovered from the marine-derived fungus Dichotomomyces cejpii F31-1, demonstrating the tremendous biosynthetic potential of this fungal strain. Among these compounds, four amides dichotomocejs A–D (1–4), one polyketide dichocetide A (5), and two diketopiperazines dichocerazines A–B (15 and 16) are new. The structures of these new compounds were determined by interpreting detailed spectroscopic data as well as calculating optical rotation values and ECD spectra. Obviously, Dichotomomyces cejpii can effectively use an amino acid-directed strategy to enhance the production of nitrogen-containing compounds. Dichotomocej A (1) displayed moderate cytotoxicity against the human rhabdomyosarcoma cell line RD with an IC50 value of 39.1 µM, and pityriacitrin (22) showed moderate cytotoxicity against the human colon carcinoma cell line HCT116 with an IC50 value of 35.1 µM.https://www.mdpi.com/1660-3397/15/11/339Dichotomomyces cejpiidiverse secondary metabolitesamino acid-directed strategynitrogen-containing compoundsbioactivity |
| spellingShingle | Yan-Xiu Chen Meng-Yang Xu Hou-Jin Li Kun-Jiao Zeng Wen-Zhe Ma Guo-Bao Tian Jun Xu De-Po Yang Wen-Jian Lan Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 Marine Drugs Dichotomomyces cejpii diverse secondary metabolites amino acid-directed strategy nitrogen-containing compounds bioactivity |
| title | Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 |
| title_full | Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 |
| title_fullStr | Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 |
| title_full_unstemmed | Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 |
| title_short | Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 |
| title_sort | diverse secondary metabolites from the marine derived fungus dichotomomyces cejpii f31 1 |
| topic | Dichotomomyces cejpii diverse secondary metabolites amino acid-directed strategy nitrogen-containing compounds bioactivity |
| url | https://www.mdpi.com/1660-3397/15/11/339 |
| work_keys_str_mv | AT yanxiuchen diversesecondarymetabolitesfromthemarinederivedfungusdichotomomycescejpiif311 AT mengyangxu diversesecondarymetabolitesfromthemarinederivedfungusdichotomomycescejpiif311 AT houjinli diversesecondarymetabolitesfromthemarinederivedfungusdichotomomycescejpiif311 AT kunjiaozeng diversesecondarymetabolitesfromthemarinederivedfungusdichotomomycescejpiif311 AT wenzhema diversesecondarymetabolitesfromthemarinederivedfungusdichotomomycescejpiif311 AT guobaotian diversesecondarymetabolitesfromthemarinederivedfungusdichotomomycescejpiif311 AT junxu diversesecondarymetabolitesfromthemarinederivedfungusdichotomomycescejpiif311 AT depoyang diversesecondarymetabolitesfromthemarinederivedfungusdichotomomycescejpiif311 AT wenjianlan diversesecondarymetabolitesfromthemarinederivedfungusdichotomomycescejpiif311 |