Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection
Distinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original Omicron variant BA.1. Here, we report the neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized Omicron BA.1-infected individuals against Omicron sublinea...
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2022-12-01
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Series: | Emerging Microbes and Infections |
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Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2022.2099305 |
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author | Chaitanya Kurhade Jing Zou Hongjie Xia Mingru Liu Qi Yang Mark Cutler David Cooper Alexander Muik Ugur Sahin Kathrin U. Jansen Ping Ren Xuping Xie Kena A. Swanson Pei-Yong Shi |
author_facet | Chaitanya Kurhade Jing Zou Hongjie Xia Mingru Liu Qi Yang Mark Cutler David Cooper Alexander Muik Ugur Sahin Kathrin U. Jansen Ping Ren Xuping Xie Kena A. Swanson Pei-Yong Shi |
author_sort | Chaitanya Kurhade |
collection | DOAJ |
description | Distinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original Omicron variant BA.1. Here, we report the neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized Omicron BA.1-infected individuals against Omicron sublineages and “Deltacron” variant (XD). BNT162b2 post-dose 3 immune sera neutralized USA-WA1/2020, Omicron BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and XD-spike SARS-CoV-2s with geometric mean titres (GMTs) of 1335, 393, 298, 315, 216, 103, and 301, respectively; thus, BA.4/5 SARS-CoV-2 spike variant showed the highest propensity to evade vaccine neutralization compared to the original Omicron variants BA.1. BA.1-convalescent sera neutralized USA-WA1/2020, BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and Deltacron-spike SARS-CoV-2s with GMTs of 15, 430, 110, 109, 102, 25, and 284, respectively. The unique mutation F486V in the BA.4/5 spike contributes to the increased evasion of antibody neutralization by sublineage BA.4/5. The low neutralization titres of vaccinated sera or convalescent sera from BA.1 infected individuals against the emerging and rapidly spreading Omicron BA.4/5 variants provide important results for consideration in the selection of an updated vaccine in the current Omicron wave.Trial registration: ClinicalTrials.gov; identifier: NCT04368728. |
first_indexed | 2024-04-12T08:19:19Z |
format | Article |
id | doaj.art-daff56ad156a43d398c1caae173a8eba |
institution | Directory Open Access Journal |
issn | 2222-1751 |
language | English |
last_indexed | 2024-04-12T08:19:19Z |
publishDate | 2022-12-01 |
publisher | Taylor & Francis Group |
record_format | Article |
series | Emerging Microbes and Infections |
spelling | doaj.art-daff56ad156a43d398c1caae173a8eba2022-12-22T03:40:41ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512022-12-011111828183210.1080/22221751.2022.2099305Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infectionChaitanya Kurhade0Jing Zou1Hongjie Xia2Mingru Liu3Qi Yang4Mark Cutler5David Cooper6Alexander Muik7Ugur Sahin8Kathrin U. Jansen9Ping Ren10Xuping Xie11Kena A. Swanson12Pei-Yong Shi13Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USADepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USADepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USADepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USAPfizer Vaccine Research and Development, Pearl River, NY, USAPfizer Vaccine Research and Development, Pearl River, NY, USAPfizer Vaccine Research and Development, Pearl River, NY, USABioNTech, Mainz, GermanyBioNTech, Mainz, GermanyPfizer Vaccine Research and Development, Pearl River, NY, USADepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USADepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USAPfizer Vaccine Research and Development, Pearl River, NY, USADepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USADistinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original Omicron variant BA.1. Here, we report the neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized Omicron BA.1-infected individuals against Omicron sublineages and “Deltacron” variant (XD). BNT162b2 post-dose 3 immune sera neutralized USA-WA1/2020, Omicron BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and XD-spike SARS-CoV-2s with geometric mean titres (GMTs) of 1335, 393, 298, 315, 216, 103, and 301, respectively; thus, BA.4/5 SARS-CoV-2 spike variant showed the highest propensity to evade vaccine neutralization compared to the original Omicron variants BA.1. BA.1-convalescent sera neutralized USA-WA1/2020, BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and Deltacron-spike SARS-CoV-2s with GMTs of 15, 430, 110, 109, 102, 25, and 284, respectively. The unique mutation F486V in the BA.4/5 spike contributes to the increased evasion of antibody neutralization by sublineage BA.4/5. The low neutralization titres of vaccinated sera or convalescent sera from BA.1 infected individuals against the emerging and rapidly spreading Omicron BA.4/5 variants provide important results for consideration in the selection of an updated vaccine in the current Omicron wave.Trial registration: ClinicalTrials.gov; identifier: NCT04368728.https://www.tandfonline.com/doi/10.1080/22221751.2022.2099305BNT162b2 vaccineSARS-CoV-2variantsneutralizationOmicron |
spellingShingle | Chaitanya Kurhade Jing Zou Hongjie Xia Mingru Liu Qi Yang Mark Cutler David Cooper Alexander Muik Ugur Sahin Kathrin U. Jansen Ping Ren Xuping Xie Kena A. Swanson Pei-Yong Shi Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection Emerging Microbes and Infections BNT162b2 vaccine SARS-CoV-2 variants neutralization Omicron |
title | Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection |
title_full | Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection |
title_fullStr | Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection |
title_full_unstemmed | Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection |
title_short | Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection |
title_sort | neutralization of omicron sublineages and deltacron sars cov 2 by three doses of bnt162b2 vaccine or ba 1 infection |
topic | BNT162b2 vaccine SARS-CoV-2 variants neutralization Omicron |
url | https://www.tandfonline.com/doi/10.1080/22221751.2022.2099305 |
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