Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8

Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8

Overexpression of c-myc via increased transcription or decreased protein degradation is common to many cancer etiologies. c-myc protein degradation is mediated by ubiquitin-dependent degradation, and this ubiquitylation is regulated by several E3 ligases. The primary regulator is Fbxw7, which binds...

Full description

Bibliographic Details
Main Authors: Sagar Bajpai, Hong Ri Jin, Bartosz Mucha, J. Alan Diehl
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Cancer Biology & Therapy
Subjects:
fbxl8
c-myc
ubiquitin ligase
cell cycle
cancer
Online Access:http://dx.doi.org/10.1080/15384047.2022.2061279

Similar Items

Similar Items