Estrogenic activity and toxicity screening of Damnacanthal nanospheres and their metabolites assessed using an in vitro bioluminescent yeast assay

Estrogenic activity and toxicity screening of Damnacanthal nanospheres and their metabolites assessed using an in vitro bioluminescent yeast assay

The root of Morinda citriforia L. (Noni) was used to extract Damnacanthal (Damna), an anthraquinone compound. In this study, Damna was successfully incorporated in N-phthaloylchitosan-grafted poly (ethylene glycol) methyl ether (PhCS-g-mPEG) to form Damna nanospheres (Damna-NS) with the particle siz...

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Bibliographic Details
Main Authors: Nutsawan Chaisutatip, Pleumchitt Rojanapanthu, Worapapar Treesuppharat, Thararat Nualsanit
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Toxicology Reports
Subjects:
Damnacanthal
Amphiphilic chitosan nanospheres
Bioluminescent yeast assay
Estrogenic activity
Metabolic activation
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750022001810

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