Development of prevalence and incidence of non-tuberculous mycobacteria in German laboratories from 2016 to 2020
ABSTRACTNumbers of non-tuberculous mycobacteria (NTM) pulmonary diseases (PD) have been repeatedly reported as increasing over the last decades, particularly in Europe. Sound epidemiological data are however missing for most European regions. This study calculated prevalence and incidence of NTM rec...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2276342 |
| _version_ | 1797257014840131584 |
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| author | Caroline Corbett Philipp Finger Marion Heiß-Neumann Juergen Bohnert Ines B. Eder Melanie Eisele Inna Friesen Achim J. Kaasch Jan Kehrmann Roland Lang Jürgen Rödel Susann Roessler Annika Schmidt Sophie Schneitler Daniela Schui Franziska Schuler Ludwig Sedlacek Annerose Serr Ana-Gabriela Sitaru Joerg Steinmann Dirk Wagner Thomas A. Wichelhaus Sabine Hofmann-Thiel Harald Hoffmann |
| author_facet | Caroline Corbett Philipp Finger Marion Heiß-Neumann Juergen Bohnert Ines B. Eder Melanie Eisele Inna Friesen Achim J. Kaasch Jan Kehrmann Roland Lang Jürgen Rödel Susann Roessler Annika Schmidt Sophie Schneitler Daniela Schui Franziska Schuler Ludwig Sedlacek Annerose Serr Ana-Gabriela Sitaru Joerg Steinmann Dirk Wagner Thomas A. Wichelhaus Sabine Hofmann-Thiel Harald Hoffmann |
| author_sort | Caroline Corbett |
| collection | DOAJ |
| description | ABSTRACTNumbers of non-tuberculous mycobacteria (NTM) pulmonary diseases (PD) have been repeatedly reported as increasing over the last decades, particularly in Europe. Sound epidemiological data are however missing for most European regions. This study calculated prevalence and incidence of NTM recovered from patients’ lungs in Germany, the largest Central European country, over a five-year period. It furthermore determined regional particularities of NTM species and results from susceptibility testing. 22 German NTM laboratories provided their mycobacteriological diagnostic data of 11,430 NTM isolates recovered from 5998 pulmonary patients representing 30% of all notified NTM-PD cases of Germany from 2016 to 2020. NTM incidence and prevalence were calculated for every study year. The presented epidemiological indicators are particularly reliant as TB surveillance data were used as a reference and TB notification reaches almost 100% in Germany. Laboratory incidence and prevalence of NTM recovered from respiratory samples ranged from 4.5–4.9 and from 5.3–5.8/100,000 for the population of Germany, respectively, and did not change over the five-year study period. Prevalence and incidence were stable also when stratifying for facultative pathogenic NTM, M. avium/intracellulare complex (MAIC), and M. abscessus/chelonae complex (MABSC). The proportion of NTM with drug susceptibility testing (DST) increased from 27.3% (2016) to 43.8% (2020). The unchanging laboratory NTM prevalence/incidence in Germany represents a “ceiling” of possible NTM-PD notification when diagnostic strategies do not change in the coming years. A notable increase in NTM-DST may indicate better notification of NTM-PD and/or awareness of new clinical guidelines but still remains below clinical needs. |
| first_indexed | 2024-03-08T11:51:49Z |
| format | Article |
| id | doaj.art-db00036ba0f549778119d33bab5e83f8 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-24T22:30:55Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-db00036ba0f549778119d33bab5e83f82024-03-19T19:34:17ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112210.1080/22221751.2023.2276342Development of prevalence and incidence of non-tuberculous mycobacteria in German laboratories from 2016 to 2020Caroline Corbett0Philipp Finger1Marion Heiß-Neumann2Juergen Bohnert3Ines B. Eder4Melanie Eisele5Inna Friesen6Achim J. Kaasch7Jan Kehrmann8Roland Lang9Jürgen Rödel10Susann Roessler11Annika Schmidt12Sophie Schneitler13Daniela Schui14Franziska Schuler15Ludwig Sedlacek16Annerose Serr17Ana-Gabriela Sitaru18Joerg Steinmann19Dirk Wagner20Thomas A. Wichelhaus21Sabine Hofmann-Thiel22Harald Hoffmann23Institute of Microbiology and Laboratory Medicine, Department IML red GmbH, WHO - Supranational Tuberculosis Reference Laboratory, Munich-Gauting, GermanyInstitute of Microbiology and Laboratory Medicine, Department IML red GmbH, WHO - Supranational Tuberculosis Reference Laboratory, Munich-Gauting, GermanyDepartment of Pneumology & Infectious Diseases, Asklepios Lung Clinic Munich-Gauting, member of the German Centre for Lung Research; Gauting, GermanyFriedrich Loeffler-Institute of Medical Microbiology, Greifswald, GermanyInstitute of Medical Microbiology and Virology, University Hospital Leipzig, Leipzig, GermanyInstitut für medizinische Mikrobiologie, Universitätsmedizin Göttingen, Göttingen, GermanyLabor Berlin - Charité Vivantes GmbH, Berlin, GermanyInstitute of Medical Microbiology and Hospital Hygiene, Medical Faculty, University Hospital Magdeburg, Otto von Guericke University, Magdeburg, GermanyInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyInstitut für Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Erlangen, GermanyInstitute of Medical Microbiology, Jena University Hospital, Friedrich Schiller University, Jena, GermanyInstitut für Medizinische Mikrobiologie und Virologie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden GermanyInstitut für medizinische Mikrobiologie und Hygiene, Tübingen, GermanyInstitute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, GermanyBioscientia Institut für Medizinische Diagnostik GmbH, Mikrobiologie, Ingelheim, GermanyInstitute of Medical Microbiology, University Hospital, Münster, GermanyInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, GermanyInstitute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, GermanyMedizinisches Versogungszentrum Clotten (MVZ) Clotten, Freiburg, GermanyInstitute of Clinical Microbiology, Infectious Diseases and Infection Control, Paracelsus Medical University, Klinikum Nürnberg, Nürnberg, GermanyDivision of Infectious Diseases, Department of Internal Medicine II, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyInstitute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Frankfurt am Main, GermanyInstitute of Microbiology and Laboratory Medicine, Department IML red GmbH, WHO - Supranational Tuberculosis Reference Laboratory, Munich-Gauting, GermanyInstitute of Microbiology and Laboratory Medicine, Department IML red GmbH, WHO - Supranational Tuberculosis Reference Laboratory, Munich-Gauting, GermanyABSTRACTNumbers of non-tuberculous mycobacteria (NTM) pulmonary diseases (PD) have been repeatedly reported as increasing over the last decades, particularly in Europe. Sound epidemiological data are however missing for most European regions. This study calculated prevalence and incidence of NTM recovered from patients’ lungs in Germany, the largest Central European country, over a five-year period. It furthermore determined regional particularities of NTM species and results from susceptibility testing. 22 German NTM laboratories provided their mycobacteriological diagnostic data of 11,430 NTM isolates recovered from 5998 pulmonary patients representing 30% of all notified NTM-PD cases of Germany from 2016 to 2020. NTM incidence and prevalence were calculated for every study year. The presented epidemiological indicators are particularly reliant as TB surveillance data were used as a reference and TB notification reaches almost 100% in Germany. Laboratory incidence and prevalence of NTM recovered from respiratory samples ranged from 4.5–4.9 and from 5.3–5.8/100,000 for the population of Germany, respectively, and did not change over the five-year study period. Prevalence and incidence were stable also when stratifying for facultative pathogenic NTM, M. avium/intracellulare complex (MAIC), and M. abscessus/chelonae complex (MABSC). The proportion of NTM with drug susceptibility testing (DST) increased from 27.3% (2016) to 43.8% (2020). The unchanging laboratory NTM prevalence/incidence in Germany represents a “ceiling” of possible NTM-PD notification when diagnostic strategies do not change in the coming years. A notable increase in NTM-DST may indicate better notification of NTM-PD and/or awareness of new clinical guidelines but still remains below clinical needs.https://www.tandfonline.com/doi/10.1080/22221751.2023.2276342Non-tuberculous mycobacteriaprevalenceincidencedrug susceptibilityNTM-pulmonary disease |
| spellingShingle | Caroline Corbett Philipp Finger Marion Heiß-Neumann Juergen Bohnert Ines B. Eder Melanie Eisele Inna Friesen Achim J. Kaasch Jan Kehrmann Roland Lang Jürgen Rödel Susann Roessler Annika Schmidt Sophie Schneitler Daniela Schui Franziska Schuler Ludwig Sedlacek Annerose Serr Ana-Gabriela Sitaru Joerg Steinmann Dirk Wagner Thomas A. Wichelhaus Sabine Hofmann-Thiel Harald Hoffmann Development of prevalence and incidence of non-tuberculous mycobacteria in German laboratories from 2016 to 2020 Emerging Microbes and Infections Non-tuberculous mycobacteria prevalence incidence drug susceptibility NTM-pulmonary disease |
| title | Development of prevalence and incidence of non-tuberculous mycobacteria in German laboratories from 2016 to 2020 |
| title_full | Development of prevalence and incidence of non-tuberculous mycobacteria in German laboratories from 2016 to 2020 |
| title_fullStr | Development of prevalence and incidence of non-tuberculous mycobacteria in German laboratories from 2016 to 2020 |
| title_full_unstemmed | Development of prevalence and incidence of non-tuberculous mycobacteria in German laboratories from 2016 to 2020 |
| title_short | Development of prevalence and incidence of non-tuberculous mycobacteria in German laboratories from 2016 to 2020 |
| title_sort | development of prevalence and incidence of non tuberculous mycobacteria in german laboratories from 2016 to 2020 |
| topic | Non-tuberculous mycobacteria prevalence incidence drug susceptibility NTM-pulmonary disease |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2276342 |
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