Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling

Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling

Summary: The human genome encodes millions of regulatory elements, of which only a small fraction are active within a given cell type. Little is known about the global impact of chromatin remodelers on regulatory DNA landscapes and how this translates to gene expression. We use precision genome engi...

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Bibliographic Details
Main Authors: John E. Lazar, Sandra Stehling-Sun, Vivek Nandakumar, Hao Wang, Daniel R. Chee, Nicholas P. Howard, Reyes Acosta, Douglass Dunn, Morgan Diegel, Fidencio Neri, Andres Castillo, Sean Ibarrientos, Kristen Lee, Ninnia Lescano, Ben Van Biber, Jemma Nelson, Jessica Halow, Richard Sandstrom, Daniel Bates, Fyodor D. Urnov, Alister P.W. Funnell, John A. Stamatoyannopoulos
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
cancer epigenetics
SMARCA4
BAF complex
gene regulation
chromatin accessibility
chromatin domains
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472030629X

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