Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation
Abstract High resolution peripheral quantitative computed tomography (HR-pQCT) provides methods for quantifying volumetric bone mineral density and microarchitecture necessary for early diagnosis of bone disease. When combined with a longitudinal imaging protocol and finite element analysis, HR-pQCT...
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| Format: | Article |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22678-z |
| _version_ | 1811335030699458560 |
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| author | Caitlyn J. Collins Penny R. Atkins Nicholas Ohs Michael Blauth Kurt Lippuner Ralph Müller |
| author_facet | Caitlyn J. Collins Penny R. Atkins Nicholas Ohs Michael Blauth Kurt Lippuner Ralph Müller |
| author_sort | Caitlyn J. Collins |
| collection | DOAJ |
| description | Abstract High resolution peripheral quantitative computed tomography (HR-pQCT) provides methods for quantifying volumetric bone mineral density and microarchitecture necessary for early diagnosis of bone disease. When combined with a longitudinal imaging protocol and finite element analysis, HR-pQCT can be used to assess bone formation and resorption (i.e., remodeling) and the relationship between this remodeling and mechanical loading (i.e., mechanoregulation) at the tissue level. Herein, 25 patients with a contralateral distal radius fracture were imaged with HR-pQCT at baseline and 9–12 months follow-up: 16 patients were prescribed vitamin D3 with/without calcium supplement based on a blood biomarker measures of bone metabolism and dual-energy X-ray absorptiometry image-based measures of normative bone quantity which indicated diminishing (n = 9) or poor (n = 7) bone quantity and 9 were not. To evaluate the sensitivity of this imaging protocol to microstructural changes, HR-pQCT images were registered for quantification of bone remodeling and image-based micro-finite element analysis was then used to predict local bone strains and derive rules for mechanoregulation. Remodeling volume fractions were predicted by both average values of trabecular and cortical thickness and bone mineral density (R2 > 0.8), whereas mechanoregulation was affected by dominance of the arm and group classification (p < 0.05). Overall, longitudinal, extended HR-pQCT analysis enabled the identification of changes in bone quantity and quality too subtle for traditional measures. |
| first_indexed | 2024-04-13T17:17:56Z |
| format | Article |
| id | doaj.art-db0204e936ac4afd94f567bccf5894ec |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T17:17:56Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-db0204e936ac4afd94f567bccf5894ec2022-12-22T02:38:04ZengNature PortfolioScientific Reports2045-23222022-10-0112111310.1038/s41598-022-22678-zClinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulationCaitlyn J. Collins0Penny R. Atkins1Nicholas Ohs2Michael Blauth3Kurt Lippuner4Ralph Müller5Institute for Biomechanics, ETH ZurichInstitute for Biomechanics, ETH ZurichInstitute for Biomechanics, ETH ZurichDepartment of Orthopedics and Trauma Surgery, Medical University of InnsbruckDepartment of Osteoporosis, Bern University Hospital, University of BernInstitute for Biomechanics, ETH ZurichAbstract High resolution peripheral quantitative computed tomography (HR-pQCT) provides methods for quantifying volumetric bone mineral density and microarchitecture necessary for early diagnosis of bone disease. When combined with a longitudinal imaging protocol and finite element analysis, HR-pQCT can be used to assess bone formation and resorption (i.e., remodeling) and the relationship between this remodeling and mechanical loading (i.e., mechanoregulation) at the tissue level. Herein, 25 patients with a contralateral distal radius fracture were imaged with HR-pQCT at baseline and 9–12 months follow-up: 16 patients were prescribed vitamin D3 with/without calcium supplement based on a blood biomarker measures of bone metabolism and dual-energy X-ray absorptiometry image-based measures of normative bone quantity which indicated diminishing (n = 9) or poor (n = 7) bone quantity and 9 were not. To evaluate the sensitivity of this imaging protocol to microstructural changes, HR-pQCT images were registered for quantification of bone remodeling and image-based micro-finite element analysis was then used to predict local bone strains and derive rules for mechanoregulation. Remodeling volume fractions were predicted by both average values of trabecular and cortical thickness and bone mineral density (R2 > 0.8), whereas mechanoregulation was affected by dominance of the arm and group classification (p < 0.05). Overall, longitudinal, extended HR-pQCT analysis enabled the identification of changes in bone quantity and quality too subtle for traditional measures.https://doi.org/10.1038/s41598-022-22678-z |
| spellingShingle | Caitlyn J. Collins Penny R. Atkins Nicholas Ohs Michael Blauth Kurt Lippuner Ralph Müller Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation Scientific Reports |
| title | Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation |
| title_full | Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation |
| title_fullStr | Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation |
| title_full_unstemmed | Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation |
| title_short | Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation |
| title_sort | clinical observation of diminished bone quality and quantity through longitudinal hr pqct derived remodeling and mechanoregulation |
| url | https://doi.org/10.1038/s41598-022-22678-z |
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