Arsenic Trioxide as a Vascular Disrupting Agent: Synergistic Effect with Irinotecan on Tumor Growth Delay in a CT26 Allograft Model

Arsenic Trioxide as a Vascular Disrupting Agent: Synergistic Effect with Irinotecan on Tumor Growth Delay in a CT26 Allograft Model

The mechanism of action of arsenic trioxide (ATO) has been shown to be complex, influencing numerous signal transduction pathways and resulting in a vast range of cellular effects. Among these mechanisms of action, ATO has been shown to cause acute vascular shutdown and massive tumor necrosis in a m...

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Bibliographic Details
Main Authors: Jong Cheo Lee, Ho Yong Lee, Chang Hoon Moon, Seung Ju Lee, Won Hyeok Lee, Hee Jeong Cha, Sungchan Park, Young Han Lee, Hyun Jin Park, Ho-Taek Song, Young Joo Min
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523313800459

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