A Peripheral CB1R Antagonist Increases Lipolysis, Oxygen Consumption Rate, and Markers of Beiging in 3T3-L1 Adipocytes Similar to RIM, Suggesting that Central Effects Can Be Avoided

A Peripheral CB1R Antagonist Increases Lipolysis, Oxygen Consumption Rate, and Markers of Beiging in 3T3-L1 Adipocytes Similar to RIM, Suggesting that Central Effects Can Be Avoided

With the increased prevalence of obesity and related co-morbidities, such as type 2 diabetes (T2D), worldwide, improvements in pharmacological treatments are necessary. The brain- and peripheral-cannabinoid receptor 1 (CB1R) antagonist rimonabant (RIM) has been shown to induce weight loss and improv...

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Bibliographic Details
Main Authors: Rebecca L. Paszkiewicz, Richard N. Bergman, Roberta S. Santos, Aaron P. Frank, Orison O. Woolcott, Malini S. Iyer, Darko Stefanovski, Deborah J. Clegg, Morvarid Kabir
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
beige adipocytes
lipolysis
CB1R antagonist
mitochondrial function
obesity
Online Access:https://www.mdpi.com/1422-0067/21/18/6639

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