Review: Multimodal bioactive material approaches for wound healing
Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collage...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2018-06-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/1.5026773 |
| _version_ | 1811216975433564160 |
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| author | Serena Mandla Locke Davenport Huyer Milica Radisic |
| author_facet | Serena Mandla Locke Davenport Huyer Milica Radisic |
| author_sort | Serena Mandla |
| collection | DOAJ |
| description | Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collagen wound dressings, are unable to meet the demand set by the wound environment. Therefore, a multifaceted bioactive dressing is needed to elicit a targeted affect. Wound healing strategies seek to develop a targeted effect through the delivery of a bioactive molecule to the wound by a hydrogel or a polymeric scaffold. This review examines current biomaterial and small molecule-based approaches that seek to develop a bioactive material for targeted wound therapy and accepted wound healing models for testing material efficacy. |
| first_indexed | 2024-04-12T06:47:27Z |
| format | Article |
| id | doaj.art-db02dced07044dd7ab148d30bd2c4ee8 |
| institution | Directory Open Access Journal |
| issn | 2473-2877 |
| language | English |
| last_indexed | 2024-04-12T06:47:27Z |
| publishDate | 2018-06-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj.art-db02dced07044dd7ab148d30bd2c4ee82022-12-22T03:43:31ZengAIP Publishing LLCAPL Bioengineering2473-28772018-06-0122021503021503-1310.1063/1.5026773016802APBReview: Multimodal bioactive material approaches for wound healingSerena Mandla0Locke Davenport Huyer1Milica Radisic2 Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, CanadaWound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collagen wound dressings, are unable to meet the demand set by the wound environment. Therefore, a multifaceted bioactive dressing is needed to elicit a targeted affect. Wound healing strategies seek to develop a targeted effect through the delivery of a bioactive molecule to the wound by a hydrogel or a polymeric scaffold. This review examines current biomaterial and small molecule-based approaches that seek to develop a bioactive material for targeted wound therapy and accepted wound healing models for testing material efficacy.http://dx.doi.org/10.1063/1.5026773 |
| spellingShingle | Serena Mandla Locke Davenport Huyer Milica Radisic Review: Multimodal bioactive material approaches for wound healing APL Bioengineering |
| title | Review: Multimodal bioactive material approaches for wound healing |
| title_full | Review: Multimodal bioactive material approaches for wound healing |
| title_fullStr | Review: Multimodal bioactive material approaches for wound healing |
| title_full_unstemmed | Review: Multimodal bioactive material approaches for wound healing |
| title_short | Review: Multimodal bioactive material approaches for wound healing |
| title_sort | review multimodal bioactive material approaches for wound healing |
| url | http://dx.doi.org/10.1063/1.5026773 |
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