Extrastriatal dopaminergic circuits of the basal ganglia
The basal ganglia are comprised of the striatum, the external and internal segment of the globus pallidus (GPe and GPi, respectively), the subthalamic nucleus (STN), and the substantia nigra pars compacta and reticulata (SNc and SNr, respectively). Dopamine has long been identified as an important...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-10-01
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| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2010.00139/full |
| _version_ | 1818790572794576896 |
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| author | Karen Suzanne Rommelfanger Thomas eWichmann Thomas eWichmann |
| author_facet | Karen Suzanne Rommelfanger Thomas eWichmann Thomas eWichmann |
| author_sort | Karen Suzanne Rommelfanger |
| collection | DOAJ |
| description | The basal ganglia are comprised of the striatum, the external and internal segment of the globus pallidus (GPe and GPi, respectively), the subthalamic nucleus (STN), and the substantia nigra pars compacta and reticulata (SNc and SNr, respectively). Dopamine has long been identified as an important modulator of basal ganglia function in the striatum, and disturbances of striatal dopaminergic transmission have been implicated in diseases such as Parkinson’s disease, addiction and attention deficit hyperactivity disorder. However, recent evidence suggests that dopamine may also modulate basal ganglia function at sites outside of the striatum, and that changes in dopaminergic transmission at these sites may contribute to the symptoms of Parkinson’s disease and other neuropsychiatric disorders. This review summarizes the current knowledge of the anatomy, functional effects and behavioral consequences of the dopaminergic innervation to the GPe, GPi, STN, and SNr. Further insights into the dopaminergic modulation of basal ganglia function at extrastriatal sites may provide us with opportunities to develop new and more specific strategies for treating disorders of basal ganglia dysfunction. |
| first_indexed | 2024-12-18T14:57:36Z |
| format | Article |
| id | doaj.art-db03cbc8ace146c0a8446f8365e4da60 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-18T14:57:36Z |
| publishDate | 2010-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-db03cbc8ace146c0a8446f8365e4da602022-12-21T21:04:00ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292010-10-01410.3389/fnana.2010.001396976Extrastriatal dopaminergic circuits of the basal gangliaKaren Suzanne Rommelfanger0Thomas eWichmann1Thomas eWichmann2Emory UniversityEmory UniversityEmory UniversityThe basal ganglia are comprised of the striatum, the external and internal segment of the globus pallidus (GPe and GPi, respectively), the subthalamic nucleus (STN), and the substantia nigra pars compacta and reticulata (SNc and SNr, respectively). Dopamine has long been identified as an important modulator of basal ganglia function in the striatum, and disturbances of striatal dopaminergic transmission have been implicated in diseases such as Parkinson’s disease, addiction and attention deficit hyperactivity disorder. However, recent evidence suggests that dopamine may also modulate basal ganglia function at sites outside of the striatum, and that changes in dopaminergic transmission at these sites may contribute to the symptoms of Parkinson’s disease and other neuropsychiatric disorders. This review summarizes the current knowledge of the anatomy, functional effects and behavioral consequences of the dopaminergic innervation to the GPe, GPi, STN, and SNr. Further insights into the dopaminergic modulation of basal ganglia function at extrastriatal sites may provide us with opportunities to develop new and more specific strategies for treating disorders of basal ganglia dysfunction.http://journal.frontiersin.org/Journal/10.3389/fnana.2010.00139/fullBasal GangliaDopamineGlobus PallidusSubstantia NigraSubthalamic NucleusGABA |
| spellingShingle | Karen Suzanne Rommelfanger Thomas eWichmann Thomas eWichmann Extrastriatal dopaminergic circuits of the basal ganglia Frontiers in Neuroanatomy Basal Ganglia Dopamine Globus Pallidus Substantia Nigra Subthalamic Nucleus GABA |
| title | Extrastriatal dopaminergic circuits of the basal ganglia |
| title_full | Extrastriatal dopaminergic circuits of the basal ganglia |
| title_fullStr | Extrastriatal dopaminergic circuits of the basal ganglia |
| title_full_unstemmed | Extrastriatal dopaminergic circuits of the basal ganglia |
| title_short | Extrastriatal dopaminergic circuits of the basal ganglia |
| title_sort | extrastriatal dopaminergic circuits of the basal ganglia |
| topic | Basal Ganglia Dopamine Globus Pallidus Substantia Nigra Subthalamic Nucleus GABA |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2010.00139/full |
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