ROS Mediate xCT-Dependent Cell Death in Human Breast Cancer Cells under Glucose Deprivation

ROS Mediate xCT-Dependent Cell Death in Human Breast Cancer Cells under Glucose Deprivation

xCT, also known as solute carrier family 7 member 11 (SLC7A11), the light chain of the cystine/glutamate antiporter, is positively correlated with cancer progression due to antioxidant function. During glucose deprivation, the overexpression of xCT does not protect cancer cells but instead promotes...

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Bibliographic Details
Main Authors: Mei-Chun Chen, Li-Lin Hsu, Sheng-Fan Wang, Chih-Yi Hsu, Hsin-Chen Lee, Ling-Ming Tseng
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
breast cancer
xCT
ROS
glucose dependency
Online Access:https://www.mdpi.com/2073-4409/9/7/1598

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