Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students
Abstract Introduction The relationship between dyslipidemia and obesity has been widely reported, but the global lipid profiles associated with the development of obesity still need to be clarified. An investigation into the association between the lipidomic plasma profile and adolescent obesity may...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-021-00859-7 |
| _version_ | 1819010662407340032 |
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| author | Ruili Yin Xiaojing Wang Kun Li Ke Yu Longyan Yang |
| author_facet | Ruili Yin Xiaojing Wang Kun Li Ke Yu Longyan Yang |
| author_sort | Ruili Yin |
| collection | DOAJ |
| description | Abstract Introduction The relationship between dyslipidemia and obesity has been widely reported, but the global lipid profiles associated with the development of obesity still need to be clarified. An investigation into the association between the lipidomic plasma profile and adolescent obesity may provide new insights into the development of obesity. Methods Mass spectrometry coupled with liquid chromatography was applied to detect the global lipidome in the fasting plasma from 90 Chinese adolescents, including 34 obese adolescents, 26 overweight adolescents, and 30 adolescents with a normal body mass index (BMI). All participants underwent anthropometric measurements by using InBody. Clinical biochemical indicators were measured by Cobas Elecsys. Results Both qualitative and quantitative analyses revealed a gradual change in plasma lipid features among obese students, exhibiting characteristics close to overweight students, but differing significantly from normal students. Compared with normal and overweight students, levels of triglyceride (TG), 18-hydroxycortisol, isohumulinone A, and 11-dihydro-12-norneoquassin were up-regulated in the obese group, while phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysoPC (LPC), lysoPE (LPE), and phosphatidylinositol (PI) were significantly down-regulated in the obese group. Then, we conducted Venn diagrams and selected 8 significant metabolites from the 3 paired comparisons. Most of the selected features were significantly correlated with the anthropometric measurements. Conclusions This study demonstrated evidence for a relationship between the eight significant metabolites with obese adolescents. These lipid features may provide a basis for evaluating risk and monitoring the development of obesity. |
| first_indexed | 2024-12-21T01:15:49Z |
| format | Article |
| id | doaj.art-db05222bc4a14c8fa88e6ac06658dd1c |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-21T01:15:49Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-db05222bc4a14c8fa88e6ac06658dd1c2022-12-21T19:20:48ZengBMCBMC Endocrine Disorders1472-68232021-10-0121111010.1186/s12902-021-00859-7Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent studentsRuili Yin0Xiaojing Wang1Kun Li2Ke Yu3Longyan Yang4Beijing Key Laboratory of Diabetes Prevention and Research, Center for Endocrine Metabolic and Immune Diseases, Beijing Luhe Hospital, Capital Medical UniversityBeijing Key Laboratory of Diabetes Prevention and Research, Center for Endocrine Metabolic and Immune Diseases, Beijing Luhe Hospital, Capital Medical UniversityBeijing Key Laboratory of Diabetes Prevention and Research, Center for Endocrine Metabolic and Immune Diseases, Beijing Luhe Hospital, Capital Medical UniversityBeijing Key Laboratory of Diabetes Prevention and Research, Center for Endocrine Metabolic and Immune Diseases, Beijing Luhe Hospital, Capital Medical UniversityBeijing Key Laboratory of Diabetes Prevention and Research, Center for Endocrine Metabolic and Immune Diseases, Beijing Luhe Hospital, Capital Medical UniversityAbstract Introduction The relationship between dyslipidemia and obesity has been widely reported, but the global lipid profiles associated with the development of obesity still need to be clarified. An investigation into the association between the lipidomic plasma profile and adolescent obesity may provide new insights into the development of obesity. Methods Mass spectrometry coupled with liquid chromatography was applied to detect the global lipidome in the fasting plasma from 90 Chinese adolescents, including 34 obese adolescents, 26 overweight adolescents, and 30 adolescents with a normal body mass index (BMI). All participants underwent anthropometric measurements by using InBody. Clinical biochemical indicators were measured by Cobas Elecsys. Results Both qualitative and quantitative analyses revealed a gradual change in plasma lipid features among obese students, exhibiting characteristics close to overweight students, but differing significantly from normal students. Compared with normal and overweight students, levels of triglyceride (TG), 18-hydroxycortisol, isohumulinone A, and 11-dihydro-12-norneoquassin were up-regulated in the obese group, while phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysoPC (LPC), lysoPE (LPE), and phosphatidylinositol (PI) were significantly down-regulated in the obese group. Then, we conducted Venn diagrams and selected 8 significant metabolites from the 3 paired comparisons. Most of the selected features were significantly correlated with the anthropometric measurements. Conclusions This study demonstrated evidence for a relationship between the eight significant metabolites with obese adolescents. These lipid features may provide a basis for evaluating risk and monitoring the development of obesity.https://doi.org/10.1186/s12902-021-00859-7LipidomicObesityOverweightAdolescence |
| spellingShingle | Ruili Yin Xiaojing Wang Kun Li Ke Yu Longyan Yang Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students BMC Endocrine Disorders Lipidomic Obesity Overweight Adolescence |
| title | Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students |
| title_full | Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students |
| title_fullStr | Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students |
| title_full_unstemmed | Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students |
| title_short | Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students |
| title_sort | lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students |
| topic | Lipidomic Obesity Overweight Adolescence |
| url | https://doi.org/10.1186/s12902-021-00859-7 |
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