Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells

Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells

Summary: Vitamin K is a micronutrient necessary for γ-carboxylation of glutamic acids. This post-translational modification occurs in the endoplasmic reticulum (ER) and affects secreted proteins. Recent clinical studies implicate vitamin K in the pathophysiology of diabetes, but the underlying molec...

Full description

Bibliographic Details
Main Authors: Julie Lacombe, Kevin Guo, Jessica Bonneau, Denis Faubert, Florian Gioanni, Alexis Vivoli, Sarah M. Muir, Soraya Hezzaz, Vincent Poitout, Mathieu Ferron
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Cell Reports
Subjects:
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723005119

Similar Items

Similar Items