Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer
Background: Colorectal cancer (CRC) is a prevalent malignancy affecting the digestive tract, and its incidence has been steadily rising over the years. Surgery remains the primary treatment modality for advanced colorectal cancer, complemented by chemotherapy. The development of drug resistance to c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1258937/full |
| _version_ | 1797685399914545152 |
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| author | Yonglong Chang Qinling Ou Qinling Ou Xuhui Zhou Kechao Nie Haixia Yan Jinhui Liu Jing Li Sifang Zhang Sifang Zhang |
| author_facet | Yonglong Chang Qinling Ou Qinling Ou Xuhui Zhou Kechao Nie Haixia Yan Jinhui Liu Jing Li Sifang Zhang Sifang Zhang |
| author_sort | Yonglong Chang |
| collection | DOAJ |
| description | Background: Colorectal cancer (CRC) is a prevalent malignancy affecting the digestive tract, and its incidence has been steadily rising over the years. Surgery remains the primary treatment modality for advanced colorectal cancer, complemented by chemotherapy. The development of drug resistance to chemotherapy is a significant contributor to treatment failure in colorectal cancer. Nanodrug delivery systems (NDDS) can significantly improve the delivery and efficacy of antitumor drugs in multiple ways. However, there is a lack of visualization of NDDS research structures and research hotspots in the field of colorectal cancer, and the elaboration of potential research areas remains to be discovered.Objective: To comprehensively explore the current research status and development trend of NDDS in CRC research.Methods: Bibliometric analysis of articles and reviews on NDDS for CRC published between 2002 and 2022 using tools including CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel was performed.Results: A total of 1866 publications authored by 9,870 individuals affiliated with 6,126 institutions across 293 countries/regions were included in the analysis. These publications appeared in 456 journals. Abnous Khalil has the highest number of publications in this field. The most published journals are the International Journal of Nanomedicine, International Journal of Pharmaceutics, and Biomaterials. Notably, the Journal of Controlled Release has the highest citation count and the third-highest H-index. Thematic analysis identified “inflammatory bowel disease”,“ “oral drug delivery," and “ulcerative colitis” as areas requiring further development. Keyword analysis revealed that “ulcerative colitis,” “exosomes,” and “as1411”have emerged as keywords within the last 2 years. These emerging keywords may become the focal points of future research.Conclusion: Our findings reveal the current research landscape and intellectual structure of NDDS in CRC research which helps researchers understand the research trends and hot spots in this field. |
| first_indexed | 2024-03-12T00:43:37Z |
| format | Article |
| id | doaj.art-db078b700aad4030bd5b52fa3ff2860e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T00:43:37Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-db078b700aad4030bd5b52fa3ff2860e2023-09-15T00:02:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-09-011410.3389/fphar.2023.12589371258937Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancerYonglong Chang0Qinling Ou1Qinling Ou2Xuhui Zhou3Kechao Nie4Haixia Yan5Jinhui Liu6Jing Li7Sifang Zhang8Sifang Zhang9Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Metabolic Diseases, Changsha, ChinaDepartment of Addiction Medicine, Hunan Institute of Mental Health, Brain Hospital of Hunan Province (The Second People’s Hospital of Hunan Province), Changsha, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaCollege of Integrated Traditional Chinese and Western Medicine, Hunan University of Traditional Chinese Medicine, Changsha, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Metabolic Diseases, Changsha, ChinaBackground: Colorectal cancer (CRC) is a prevalent malignancy affecting the digestive tract, and its incidence has been steadily rising over the years. Surgery remains the primary treatment modality for advanced colorectal cancer, complemented by chemotherapy. The development of drug resistance to chemotherapy is a significant contributor to treatment failure in colorectal cancer. Nanodrug delivery systems (NDDS) can significantly improve the delivery and efficacy of antitumor drugs in multiple ways. However, there is a lack of visualization of NDDS research structures and research hotspots in the field of colorectal cancer, and the elaboration of potential research areas remains to be discovered.Objective: To comprehensively explore the current research status and development trend of NDDS in CRC research.Methods: Bibliometric analysis of articles and reviews on NDDS for CRC published between 2002 and 2022 using tools including CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel was performed.Results: A total of 1866 publications authored by 9,870 individuals affiliated with 6,126 institutions across 293 countries/regions were included in the analysis. These publications appeared in 456 journals. Abnous Khalil has the highest number of publications in this field. The most published journals are the International Journal of Nanomedicine, International Journal of Pharmaceutics, and Biomaterials. Notably, the Journal of Controlled Release has the highest citation count and the third-highest H-index. Thematic analysis identified “inflammatory bowel disease”,“ “oral drug delivery," and “ulcerative colitis” as areas requiring further development. Keyword analysis revealed that “ulcerative colitis,” “exosomes,” and “as1411”have emerged as keywords within the last 2 years. These emerging keywords may become the focal points of future research.Conclusion: Our findings reveal the current research landscape and intellectual structure of NDDS in CRC research which helps researchers understand the research trends and hot spots in this field.https://www.frontiersin.org/articles/10.3389/fphar.2023.1258937/fullcolorectal cancernano-drug delivery systembibliometric analysisvisualizationR-bibliometrixresearch trends |
| spellingShingle | Yonglong Chang Qinling Ou Qinling Ou Xuhui Zhou Kechao Nie Haixia Yan Jinhui Liu Jing Li Sifang Zhang Sifang Zhang Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer Frontiers in Pharmacology colorectal cancer nano-drug delivery system bibliometric analysis visualization R-bibliometrix research trends |
| title | Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer |
| title_full | Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer |
| title_fullStr | Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer |
| title_full_unstemmed | Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer |
| title_short | Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer |
| title_sort | mapping the intellectual structure and landscape of nano drug delivery systems in colorectal cancer |
| topic | colorectal cancer nano-drug delivery system bibliometric analysis visualization R-bibliometrix research trends |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1258937/full |
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