A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease
Objective: To analyze outcomes and complications of cytoreductive prostatectomy (CRP) for oligometastatic prostate cancer (PCa) in order to elucidate its role in this space. Methods: We performed a systematic literature search using three databases (Medline, Scopus, and Web of Science). The primary...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Asian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388222001436 |
| _version_ | 1797198817572945920 |
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| author | Andrey Morozov Leonid Chuvalov Mark Taratkin Mikhail Enikeev Leonid Rapoport Nirmish Singla Eric Barret Elena Poddubskaya Maria Borodina Georg Salomon Juan Gomez Rivas Dmitry Enikeev |
| author_facet | Andrey Morozov Leonid Chuvalov Mark Taratkin Mikhail Enikeev Leonid Rapoport Nirmish Singla Eric Barret Elena Poddubskaya Maria Borodina Georg Salomon Juan Gomez Rivas Dmitry Enikeev |
| author_sort | Andrey Morozov |
| collection | DOAJ |
| description | Objective: To analyze outcomes and complications of cytoreductive prostatectomy (CRP) for oligometastatic prostate cancer (PCa) in order to elucidate its role in this space. Methods: We performed a systematic literature search using three databases (Medline, Scopus, and Web of Science). The primary endpoints were oncologic outcomes. The secondary endpoints were complication rates and functional results. Results: In all studies, overall survival was better or at least comparable variable in the groups with CRP compared to no local treatment. The greatest benefit from CRP in 5-year overall survival in one study was 67.4% for CRP versus 22.5% for no local treatment. Cancer-specific survival (CSS) showed the same trend. Several authors found significant benefits from CSS in the CRP group: from 79% vs. 46% to 100% vs. 61%. CRP was a predictor of better CSS (hazard ratio 0.264, p=0.004). Positive surgical margin rates differed widely from 28.6% to 100.0%. Urinary continence in CRP versus RP for localized PCa was significantly lower (57.4% vs. 90.8%, p<0.0001). Severe incontinence occurred seldom (2.5%–18.6%). Total complication rates after CRP differed widely, from 7.0% to 43.6%. Rates of grades 1 and 2 events prevailed. Patients on ADT alone also showed a considerable number of complications varying from 5.9% to 57.7%. Conclusion: CRP improves medium-term cancer control in patients with oligometastatic PCa. The morbidity and complication rates of this surgery are comparable with other approaches, but postoperative incontinence rate is higher compared with RP for localized disease. |
| first_indexed | 2024-04-24T07:05:53Z |
| format | Article |
| id | doaj.art-db0994548cdc4ce6abfe0c756debbd54 |
| institution | Directory Open Access Journal |
| issn | 2214-3882 |
| language | English |
| last_indexed | 2024-04-24T07:05:53Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj.art-db0994548cdc4ce6abfe0c756debbd542024-04-22T04:11:40ZengElsevierAsian Journal of Urology2214-38822024-04-01112208220A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic diseaseAndrey Morozov0Leonid Chuvalov1Mark Taratkin2Mikhail Enikeev3Leonid Rapoport4Nirmish Singla5Eric Barret6Elena Poddubskaya7Maria Borodina8Georg Salomon9Juan Gomez Rivas10Dmitry Enikeev11Institute for Urology and Reproductive Health, Sechenov University, Moscow, RussiaInstitute for Urology and Reproductive Health, Sechenov University, Moscow, RussiaInstitute for Urology and Reproductive Health, Sechenov University, Moscow, Russia; Young Academic Urologists, EAU, the NetherlandsInstitute for Urology and Reproductive Health, Sechenov University, Moscow, RussiaInstitute for Urology and Reproductive Health, Sechenov University, Moscow, RussiaDepartment of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, USADepartment of Urology, Institut Mutualiste Montsouris, Paris, FranceSechenov University, Moscow, RussiaHertsen Moscow Oncology Research Institute, Moscow, RussiaMartini Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Urology, Clinico San Carlos University Hospital, Madrid, SpainInstitute for Urology and Reproductive Health, Sechenov University, Moscow, Russia; Department of Urology, Medical University of Vienna, Vienna, Austria; Corresponding author. Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia.Objective: To analyze outcomes and complications of cytoreductive prostatectomy (CRP) for oligometastatic prostate cancer (PCa) in order to elucidate its role in this space. Methods: We performed a systematic literature search using three databases (Medline, Scopus, and Web of Science). The primary endpoints were oncologic outcomes. The secondary endpoints were complication rates and functional results. Results: In all studies, overall survival was better or at least comparable variable in the groups with CRP compared to no local treatment. The greatest benefit from CRP in 5-year overall survival in one study was 67.4% for CRP versus 22.5% for no local treatment. Cancer-specific survival (CSS) showed the same trend. Several authors found significant benefits from CSS in the CRP group: from 79% vs. 46% to 100% vs. 61%. CRP was a predictor of better CSS (hazard ratio 0.264, p=0.004). Positive surgical margin rates differed widely from 28.6% to 100.0%. Urinary continence in CRP versus RP for localized PCa was significantly lower (57.4% vs. 90.8%, p<0.0001). Severe incontinence occurred seldom (2.5%–18.6%). Total complication rates after CRP differed widely, from 7.0% to 43.6%. Rates of grades 1 and 2 events prevailed. Patients on ADT alone also showed a considerable number of complications varying from 5.9% to 57.7%. Conclusion: CRP improves medium-term cancer control in patients with oligometastatic PCa. The morbidity and complication rates of this surgery are comparable with other approaches, but postoperative incontinence rate is higher compared with RP for localized disease.http://www.sciencedirect.com/science/article/pii/S2214388222001436Systematic reviewProstate cancerOligometastaticBone metastasesCytoreductive prostatectomy |
| spellingShingle | Andrey Morozov Leonid Chuvalov Mark Taratkin Mikhail Enikeev Leonid Rapoport Nirmish Singla Eric Barret Elena Poddubskaya Maria Borodina Georg Salomon Juan Gomez Rivas Dmitry Enikeev A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease Asian Journal of Urology Systematic review Prostate cancer Oligometastatic Bone metastases Cytoreductive prostatectomy |
| title | A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease |
| title_full | A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease |
| title_fullStr | A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease |
| title_full_unstemmed | A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease |
| title_short | A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease |
| title_sort | systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease |
| topic | Systematic review Prostate cancer Oligometastatic Bone metastases Cytoreductive prostatectomy |
| url | http://www.sciencedirect.com/science/article/pii/S2214388222001436 |
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