mTOR inhibitor INK128 promotes wound healing by regulating MDSCs

mTOR inhibitor INK128 promotes wound healing by regulating MDSCs

Abstract Background Skin wounds in diabetic patients hardly recover. Accumulating evidence has shown that mammalian target of rapamycin (mTOR) pathway and myeloid-derived suppressor cells (MDSCs) are involved in inflammatory-related response. INK128 is a novel mTOR kinase inhibitor in clinical devel...

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Bibliographic Details
Main Authors: Yi Li, Yujun Xu, Xinhan Liu, Xin Yan, Yue Lin, Qian Tan, Yayi Hou
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Stem Cell Research & Therapy
Subjects:
Myeloid-derived suppressor cells
Immunology
Wound healing
Macrophages
Online Access:https://doi.org/10.1186/s13287-021-02206-y

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