Integrated network pharmacology and experimental verification to investigate the mechanisms of YYFZBJS against colorectal cancer via CDK1/PI3K/Akt signaling

Integrated network pharmacology and experimental verification to investigate the mechanisms of YYFZBJS against colorectal cancer via CDK1/PI3K/Akt signaling

BackgroundColorectal cancer (CRC) is a common digestive tract malignancy with rising incidence and morbidity worldwide during recent years. Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS), a traditional Chinese medicine formula, has showed positive effects against cancers. However, the mechanisms underlying its...

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Bibliographic Details
Main Authors: Jinxiao Li, Fangyuan Zhou, Luorui Shang, Na Liu, Yuhan Liu, Mengqi Zhang, Shuhan Wang, Shenglan Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
YYFZBJS
colorectal cancer
network pharmacology
PI3K/Akt pathway
apoptosis
cell cycle
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.961653/full

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