BRAF-Inhibitor-Induced Metabolic Alterations in A375 Melanoma Cells

Acquired drug tolerance has been a major challenge in cancer therapy. Recent evidence has revealed the existence of slow-cycling persister cells that survive drug treatments and give rise to multi-drug-tolerant mutants in cancer. Cells in this dynamic persister state can escape drug treatment by und...

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Bibliographic Details
Main Authors: Prashant Karki, Shayne Sensenbach, Vahideh Angardi, Mehmet A. Orman
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Metabolites
Subjects:
Online Access:https://www.mdpi.com/2218-1989/11/11/777