High-Throughput Mechanistic Screening of Epigenetic Compounds for the Potential Treatment of Meningiomas

High-Throughput Mechanistic Screening of Epigenetic Compounds for the Potential Treatment of Meningiomas

Background: Meningiomas are the most common primary central nervous system tumors. 20–30% of these tumors are considered high-grade and associated with poor prognosis and high recurrence rates. Despite the high occurrence of meningiomas, there are no FDA-approved compounds for the treatment of these...

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Bibliographic Details
Main Authors: Philip D. Tatman, Tadeusz H. Wroblewski, Anthony R. Fringuello, Samuel R. Scherer, William B. Foreman, Denise M. Damek, Kevin Lillehei, A. Samy Youssef, Randy L. Jensen, Michael W. Graner, D. Ryan Ormond
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Journal of Clinical Medicine
Subjects:
meningioma
HDAC inhibitors
panobinostat
LAQ824
HC toxin
high-throughput screening
Online Access:https://www.mdpi.com/2077-0383/10/14/3150

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