Bisphenol A, TH17 cells, and allergy: a commentary
There is a continuing interest in whether Bisphenol A (BPA) is able to cause adverse health effects through interaction with elements of the immune system. That interest has been fuelled further by the recent publication of a draft opinion on BPA prepared by the European Food Safety Authority (EFSA)...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Journal of Immunotoxicology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/1547691X.2022.2113842 |
| _version_ | 1798002257129635840 |
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| author | Ian Kimber Nicole Woeffen Kevin Sondenheimer |
| author_facet | Ian Kimber Nicole Woeffen Kevin Sondenheimer |
| author_sort | Ian Kimber |
| collection | DOAJ |
| description | There is a continuing interest in whether Bisphenol A (BPA) is able to cause adverse health effects through interaction with elements of the immune system. That interest has been fuelled further by the recent publication of a draft opinion on BPA prepared by the European Food Safety Authority (EFSA) Panel on Food Contact Materials, Enzymes and Processing Aids (CEP). This draft opinion judged effects on the immune system to be the most sensitive health outcome, and identified BPA-induced changes in the frequency of T-helper (TH)-17 cells in the spleens of mice as being the critical effect based on an association of these cells with inflammation. Based on these evaluations the CEP Panel recommended that a revised Tolerable Daily Intake (TDI) for BPA of 0.04 ng/kg bw/day should be adopted; representing a very substantial reduction (100,000-fold) compared with the existing TDI. The purpose of this commentary is to summarize briefly the role of TH17 cells in immune responses, and to review relevant literature regarding the influence of BPA on these cells, and on inflammatory responses in the lung and respiratory allergy. The conclusion drawn is that based on uncertainties about the effects of BPA on TH17 cells and lung inflammation in mice, the absence of consistent or persuasive evidence from human studies that exposure of BPA is associated with inflammation or allergy, and unresolved questions regarding the species selectivity of immune effects induced by BPA, it is inappropriate to adopt the revised TDI. Additional research is required to explore further the influence of BPA on the immune system and immune responses. |
| first_indexed | 2024-04-11T11:49:10Z |
| format | Article |
| id | doaj.art-db102e5e23304531ae5e59c75693067c |
| institution | Directory Open Access Journal |
| issn | 1547-691X 1547-6901 |
| language | English |
| last_indexed | 2024-04-11T11:49:10Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Immunotoxicology |
| spelling | doaj.art-db102e5e23304531ae5e59c75693067c2022-12-22T04:25:26ZengTaylor & Francis GroupJournal of Immunotoxicology1547-691X1547-69012022-12-01191939910.1080/1547691X.2022.2113842Bisphenol A, TH17 cells, and allergy: a commentaryIan Kimber0Nicole Woeffen1Kevin Sondenheimer2Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UKCovestro Deutschland AG, Leverkusen, GermanyCovestro Deutschland AG, Leverkusen, GermanyThere is a continuing interest in whether Bisphenol A (BPA) is able to cause adverse health effects through interaction with elements of the immune system. That interest has been fuelled further by the recent publication of a draft opinion on BPA prepared by the European Food Safety Authority (EFSA) Panel on Food Contact Materials, Enzymes and Processing Aids (CEP). This draft opinion judged effects on the immune system to be the most sensitive health outcome, and identified BPA-induced changes in the frequency of T-helper (TH)-17 cells in the spleens of mice as being the critical effect based on an association of these cells with inflammation. Based on these evaluations the CEP Panel recommended that a revised Tolerable Daily Intake (TDI) for BPA of 0.04 ng/kg bw/day should be adopted; representing a very substantial reduction (100,000-fold) compared with the existing TDI. The purpose of this commentary is to summarize briefly the role of TH17 cells in immune responses, and to review relevant literature regarding the influence of BPA on these cells, and on inflammatory responses in the lung and respiratory allergy. The conclusion drawn is that based on uncertainties about the effects of BPA on TH17 cells and lung inflammation in mice, the absence of consistent or persuasive evidence from human studies that exposure of BPA is associated with inflammation or allergy, and unresolved questions regarding the species selectivity of immune effects induced by BPA, it is inappropriate to adopt the revised TDI. Additional research is required to explore further the influence of BPA on the immune system and immune responses.https://www.tandfonline.com/doi/10.1080/1547691X.2022.2113842Bisphenol ATH17 cellsallergyasthmaIgE antibody |
| spellingShingle | Ian Kimber Nicole Woeffen Kevin Sondenheimer Bisphenol A, TH17 cells, and allergy: a commentary Journal of Immunotoxicology Bisphenol A TH17 cells allergy asthma IgE antibody |
| title | Bisphenol A, TH17 cells, and allergy: a commentary |
| title_full | Bisphenol A, TH17 cells, and allergy: a commentary |
| title_fullStr | Bisphenol A, TH17 cells, and allergy: a commentary |
| title_full_unstemmed | Bisphenol A, TH17 cells, and allergy: a commentary |
| title_short | Bisphenol A, TH17 cells, and allergy: a commentary |
| title_sort | bisphenol a th17 cells and allergy a commentary |
| topic | Bisphenol A TH17 cells allergy asthma IgE antibody |
| url | https://www.tandfonline.com/doi/10.1080/1547691X.2022.2113842 |
| work_keys_str_mv | AT iankimber bisphenolath17cellsandallergyacommentary AT nicolewoeffen bisphenolath17cellsandallergyacommentary AT kevinsondenheimer bisphenolath17cellsandallergyacommentary |