Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort
Prenatal exposure to phthalates, a family of endocrine-disrupting plasticizers, is associated with disruption of maternal metabolism and impaired neurodevelopment. We investigated associations between prenatal phthalate exposure and alterations of both the maternal third trimester serum metabolome a...
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MDPI AG
2022-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/9/829 |
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| author | Mariana Parenti Rebecca J. Schmidt Sally Ozonoff Hyeong-Moo Shin Daniel J. Tancredi Paula Krakowiak Irva Hertz-Picciotto Cheryl K. Walker Carolyn M. Slupsky |
| author_facet | Mariana Parenti Rebecca J. Schmidt Sally Ozonoff Hyeong-Moo Shin Daniel J. Tancredi Paula Krakowiak Irva Hertz-Picciotto Cheryl K. Walker Carolyn M. Slupsky |
| author_sort | Mariana Parenti |
| collection | DOAJ |
| description | Prenatal exposure to phthalates, a family of endocrine-disrupting plasticizers, is associated with disruption of maternal metabolism and impaired neurodevelopment. We investigated associations between prenatal phthalate exposure and alterations of both the maternal third trimester serum metabolome and the placental metabolome at birth, and associations of these with child neurodevelopmental outcomes using data and samples from the Markers of Autism Risk in Babies Learning Early Signs (MARBLES) cohort. The third trimester serum (<i>n</i> = 106) and placental (<i>n</i> = 132) metabolomes were investigated using <sup>1</sup>H nuclear magnetic resonance spectroscopy. Children were assessed clinically for autism spectrum disorder (ASD) and cognitive development. Although none of the urinary phthalate metabolite concentrations were associated with maternal serum metabolites after adjustment for covariates, mixture analysis using quantile g-computation revealed alterations in placental metabolites with increasing concentrations of phthalate metabolites that included reduced concentrations of 2-hydoxybutyrate, carnitine, <i>O</i>-acetylcarnitine, glucitol, and <i>N</i>-acetylneuraminate. Child neurodevelopmental outcome was not associated with the third trimester serum metabolome, but it was correlated with the placental metabolome in male children only. Maternal phthalate exposure during pregnancy is associated with differences in the placental metabolome at delivery, and the placental metabolome is associated with neurodevelopmental outcomes in males in a cohort with high familial ASD risk. |
| first_indexed | 2024-03-09T23:11:12Z |
| format | Article |
| id | doaj.art-db10e6a701d74eee88595fbcd73b8561 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T23:11:12Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-db10e6a701d74eee88595fbcd73b85612023-11-23T17:44:20ZengMDPI AGMetabolites2218-19892022-09-0112982910.3390/metabo12090829Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES CohortMariana Parenti0Rebecca J. Schmidt1Sally Ozonoff2Hyeong-Moo Shin3Daniel J. Tancredi4Paula Krakowiak5Irva Hertz-Picciotto6Cheryl K. Walker7Carolyn M. Slupsky8Department of Nutrition, University of California, Davis, CA 95616, USADepartment of Public Health Sciences, University of California, Davis, CA 95616, USAMedical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, CA 95616, USADepartment of Environmental Science, Baylor University, Waco, TX 76798, USADepartment of Pediatrics, School of Medicine, University of California, Davis, CA 95616, USADepartment of Public Health Sciences, University of California, Davis, CA 95616, USADepartment of Public Health Sciences, University of California, Davis, CA 95616, USAMedical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, CA 95616, USADepartment of Nutrition, University of California, Davis, CA 95616, USAPrenatal exposure to phthalates, a family of endocrine-disrupting plasticizers, is associated with disruption of maternal metabolism and impaired neurodevelopment. We investigated associations between prenatal phthalate exposure and alterations of both the maternal third trimester serum metabolome and the placental metabolome at birth, and associations of these with child neurodevelopmental outcomes using data and samples from the Markers of Autism Risk in Babies Learning Early Signs (MARBLES) cohort. The third trimester serum (<i>n</i> = 106) and placental (<i>n</i> = 132) metabolomes were investigated using <sup>1</sup>H nuclear magnetic resonance spectroscopy. Children were assessed clinically for autism spectrum disorder (ASD) and cognitive development. Although none of the urinary phthalate metabolite concentrations were associated with maternal serum metabolites after adjustment for covariates, mixture analysis using quantile g-computation revealed alterations in placental metabolites with increasing concentrations of phthalate metabolites that included reduced concentrations of 2-hydoxybutyrate, carnitine, <i>O</i>-acetylcarnitine, glucitol, and <i>N</i>-acetylneuraminate. Child neurodevelopmental outcome was not associated with the third trimester serum metabolome, but it was correlated with the placental metabolome in male children only. Maternal phthalate exposure during pregnancy is associated with differences in the placental metabolome at delivery, and the placental metabolome is associated with neurodevelopmental outcomes in males in a cohort with high familial ASD risk.https://www.mdpi.com/2218-1989/12/9/829autismphthalatesprenatal exposureNMRplacentaserum |
| spellingShingle | Mariana Parenti Rebecca J. Schmidt Sally Ozonoff Hyeong-Moo Shin Daniel J. Tancredi Paula Krakowiak Irva Hertz-Picciotto Cheryl K. Walker Carolyn M. Slupsky Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort Metabolites autism phthalates prenatal exposure NMR placenta serum |
| title | Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort |
| title_full | Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort |
| title_fullStr | Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort |
| title_full_unstemmed | Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort |
| title_short | Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort |
| title_sort | maternal serum and placental metabolomes in association with prenatal phthalate exposure and neurodevelopmental outcomes in the marbles cohort |
| topic | autism phthalates prenatal exposure NMR placenta serum |
| url | https://www.mdpi.com/2218-1989/12/9/829 |
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