Aryl hydrocarbon receptor controls regulatory CD4+T cell function
The ligand activated transcription factor aryl hydrocarbon receptor (AhR) has been studied for many decades in toxicology as the ligand for the environmental contaminant dioxin. However, AhR has recently emerged as a critical physiological regulator of immune responses affecting both innate an...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2012-05-01
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| Series: | Swiss Medical Weekly |
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| Online Access: | https://www.smw.ch/index.php/smw/article/view/1494 |
| _version_ | 1811194123161436160 |
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| author | Caroline Pot |
| author_facet | Caroline Pot |
| author_sort | Caroline Pot |
| collection | DOAJ |
| description |
The ligand activated transcription factor aryl hydrocarbon receptor (AhR) has been studied for many decades in toxicology as the ligand for the environmental contaminant dioxin. However, AhR has recently emerged as a critical physiological regulator of immune responses affecting both innate and adaptive systems, and several AhR ligands with different pharmacological profiles have recently been studied. The current review discusses new insights into the role of AhR signalling and AhR ligands on the regulation of the immune system, with a focus on regulatory T cells which maintain immune tolerance. Notably, AhR is expressed and modulates the development of two induced regulatory CD4+ T cell subsets, the forkhead box P3-positive (Foxp3+) regulatory T cells (iTreg) and the IL-10-secreting type 1 regulatory T (TR1) cells, through different signalling pathways. We will finally discuss how AhR ligands could be exploited to alleviate human autoimmune diseases. Clearly, drugs targeted against AhR should promote the development of new strategies to fight against autoimmune diseases.
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| first_indexed | 2024-04-12T00:20:41Z |
| format | Article |
| id | doaj.art-db1179dbbc4b4519be2cb2ed9540cd04 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-12T00:20:41Z |
| publishDate | 2012-05-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-db1179dbbc4b4519be2cb2ed9540cd042022-12-22T03:55:44ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972012-05-01142212210.4414/smw.2012.13592Aryl hydrocarbon receptor controls regulatory CD4+T cell functionCaroline Pot The ligand activated transcription factor aryl hydrocarbon receptor (AhR) has been studied for many decades in toxicology as the ligand for the environmental contaminant dioxin. However, AhR has recently emerged as a critical physiological regulator of immune responses affecting both innate and adaptive systems, and several AhR ligands with different pharmacological profiles have recently been studied. The current review discusses new insights into the role of AhR signalling and AhR ligands on the regulation of the immune system, with a focus on regulatory T cells which maintain immune tolerance. Notably, AhR is expressed and modulates the development of two induced regulatory CD4+ T cell subsets, the forkhead box P3-positive (Foxp3+) regulatory T cells (iTreg) and the IL-10-secreting type 1 regulatory T (TR1) cells, through different signalling pathways. We will finally discuss how AhR ligands could be exploited to alleviate human autoimmune diseases. Clearly, drugs targeted against AhR should promote the development of new strategies to fight against autoimmune diseases. https://www.smw.ch/index.php/smw/article/view/1494aryl hydrocarbon receptoraryl hydrocarbon receptor ligandsautoimmunity.Foxp3 regulatory T cellsTCDDtolerance |
| spellingShingle | Caroline Pot Aryl hydrocarbon receptor controls regulatory CD4+T cell function Swiss Medical Weekly aryl hydrocarbon receptor aryl hydrocarbon receptor ligands autoimmunity. Foxp3 regulatory T cells TCDD tolerance |
| title | Aryl hydrocarbon receptor controls regulatory CD4+T cell function |
| title_full | Aryl hydrocarbon receptor controls regulatory CD4+T cell function |
| title_fullStr | Aryl hydrocarbon receptor controls regulatory CD4+T cell function |
| title_full_unstemmed | Aryl hydrocarbon receptor controls regulatory CD4+T cell function |
| title_short | Aryl hydrocarbon receptor controls regulatory CD4+T cell function |
| title_sort | aryl hydrocarbon receptor controls regulatory cd4 t cell function |
| topic | aryl hydrocarbon receptor aryl hydrocarbon receptor ligands autoimmunity. Foxp3 regulatory T cells TCDD tolerance |
| url | https://www.smw.ch/index.php/smw/article/view/1494 |
| work_keys_str_mv | AT carolinepot arylhydrocarbonreceptorcontrolsregulatorycd4tcellfunction |