Role of Akt/Protein Kinase B in Cancer Metastasis
Metastasis is a critical step in the process of carcinogenesis and a vast majority of cancer-related mortalities result from metastatic disease that is resistant to current therapies. Cell migration and invasion are the first steps of the metastasis process, which mainly occurs by two important biol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/11/3001 |
| _version_ | 1797460078724382720 |
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| author | Mohammad Islam Sarah Jones Ian Ellis |
| author_facet | Mohammad Islam Sarah Jones Ian Ellis |
| author_sort | Mohammad Islam |
| collection | DOAJ |
| description | Metastasis is a critical step in the process of carcinogenesis and a vast majority of cancer-related mortalities result from metastatic disease that is resistant to current therapies. Cell migration and invasion are the first steps of the metastasis process, which mainly occurs by two important biological mechanisms, i.e., cytoskeletal remodelling and epithelial to mesenchymal transition (EMT). Akt (also known as protein kinase B) is a central signalling molecule of the PI3K-Akt signalling pathway. Aberrant activation of this pathway has been identified in a wide range of cancers. Several studies have revealed that Akt actively engages with the migratory process in motile cells, including metastatic cancer cells. The downstream signalling mechanism of Akt in cell migration depends upon the tumour type, sites, and intracellular localisation of activated Akt. In this review, we focus on the role of Akt in the regulation of two events that control cell migration and invasion in various cancers including head and neck squamous cell carcinoma (HNSCC) and the status of PI3K-Akt pathway inhibitors in clinical trials in metastatic cancers. |
| first_indexed | 2024-03-09T17:00:06Z |
| format | Article |
| id | doaj.art-db118411640c4554826e8ae77c5a3a9b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:00:06Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-db118411640c4554826e8ae77c5a3a9b2023-11-24T14:31:07ZengMDPI AGBiomedicines2227-90592023-11-011111300110.3390/biomedicines11113001Role of Akt/Protein Kinase B in Cancer MetastasisMohammad Islam0Sarah Jones1Ian Ellis2Unit of Cell and Molecular Biology, School of Dentistry, University of Dundee, Park Place, Dundee DD1 4HR, UKUnit of Cell and Molecular Biology, School of Dentistry, University of Dundee, Park Place, Dundee DD1 4HR, UKUnit of Cell and Molecular Biology, School of Dentistry, University of Dundee, Park Place, Dundee DD1 4HR, UKMetastasis is a critical step in the process of carcinogenesis and a vast majority of cancer-related mortalities result from metastatic disease that is resistant to current therapies. Cell migration and invasion are the first steps of the metastasis process, which mainly occurs by two important biological mechanisms, i.e., cytoskeletal remodelling and epithelial to mesenchymal transition (EMT). Akt (also known as protein kinase B) is a central signalling molecule of the PI3K-Akt signalling pathway. Aberrant activation of this pathway has been identified in a wide range of cancers. Several studies have revealed that Akt actively engages with the migratory process in motile cells, including metastatic cancer cells. The downstream signalling mechanism of Akt in cell migration depends upon the tumour type, sites, and intracellular localisation of activated Akt. In this review, we focus on the role of Akt in the regulation of two events that control cell migration and invasion in various cancers including head and neck squamous cell carcinoma (HNSCC) and the status of PI3K-Akt pathway inhibitors in clinical trials in metastatic cancers.https://www.mdpi.com/2227-9059/11/11/3001AktcancermetastasisHNSCCEMTcytoskeletal remodelling |
| spellingShingle | Mohammad Islam Sarah Jones Ian Ellis Role of Akt/Protein Kinase B in Cancer Metastasis Biomedicines Akt cancer metastasis HNSCC EMT cytoskeletal remodelling |
| title | Role of Akt/Protein Kinase B in Cancer Metastasis |
| title_full | Role of Akt/Protein Kinase B in Cancer Metastasis |
| title_fullStr | Role of Akt/Protein Kinase B in Cancer Metastasis |
| title_full_unstemmed | Role of Akt/Protein Kinase B in Cancer Metastasis |
| title_short | Role of Akt/Protein Kinase B in Cancer Metastasis |
| title_sort | role of akt protein kinase b in cancer metastasis |
| topic | Akt cancer metastasis HNSCC EMT cytoskeletal remodelling |
| url | https://www.mdpi.com/2227-9059/11/11/3001 |
| work_keys_str_mv | AT mohammadislam roleofaktproteinkinasebincancermetastasis AT sarahjones roleofaktproteinkinasebincancermetastasis AT ianellis roleofaktproteinkinasebincancermetastasis |