Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality?
Objectives: SARS-CoV-2 is responsible for the global COVID-19 pandemic, with little prevention or treatment options. More than 600 million mortalities have been documented from SARS-CoV-2 infection, with the majority of fatalities occurring among elderly patients (aged >65 years). A number of vac...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222004982 |
| _version_ | 1817979633768857600 |
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| author | Yiran E. Li Shuyi Wang Russel J. Reiter Jun Ren |
| author_facet | Yiran E. Li Shuyi Wang Russel J. Reiter Jun Ren |
| author_sort | Yiran E. Li |
| collection | DOAJ |
| description | Objectives: SARS-CoV-2 is responsible for the global COVID-19 pandemic, with little prevention or treatment options. More than 600 million mortalities have been documented from SARS-CoV-2 infection, with the majority of fatalities occurring among elderly patients (aged >65 years). A number of vaccines have been developed in an effort to restrain the rapid spread of SARS-CoV-2. Considering the widespread administration of these vaccines, substantial side or undesired effects in multiple organ systems have emerged, necessitating essential critical care. Herein, we tabulate the adverse cardiovascular responses resulting from COVID-19 vaccines. Design or Methods: We searched PubMed for articles published through April, 2022, with the terms “SARS-CoV-2”, “COVID-19”, “cardiovascular”, “SARS-CoV-2 vaccines”, “COVID-19 vaccines”, “myocarditis”, “pericarditis”, “thrombosis”, “thrombocytopenia”, “vaccine-induced thrombotic thrombocytopenia”, “acute coronary syndrome”, “myocardial infarction”, “hypertension”, “arrythmia”, “postural orthostatic tachycardia syndrome”, “Takotsubo cardiomyopathy”, “cardiac arrest” and “death”. We mainly selected publications from the past 3 years, but did not exclude widely referenced and highly regarded older publications. Besides, we searched the reference lists of articles identified by above search method and chose those we considered relevant. Results: COVID-19 vaccines evoke rare but fatal thrombotic events, whereas messenger RNA/055based vaccines appear to be associated with risks of pericarditis/myocarditis, with the latter being more predominant in young adults following the second dose. Reports of other cardiovascular responses, including hypertension, arrhythmia, acute coronary syndrome, and cardiac arrest, have also been indicated. Conclusion: The undesired cardiovascular complications remain infrequent, giveng the large number of vaccinations inoculated to general population. And lower mortality takes precedence over the undesired cardiovascular complications. |
| first_indexed | 2024-04-13T22:45:03Z |
| format | Article |
| id | doaj.art-db135d43afa04604817a83d4a7b778a3 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-13T22:45:03Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-db135d43afa04604817a83d4a7b778a32022-12-22T02:26:27ZengElsevierInternational Journal of Infectious Diseases1201-97122022-11-01124110Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality?Yiran E. Li0Shuyi Wang1Russel J. Reiter2Jun Ren3Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, ChinaDepartment of Emergency, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, ChinaDepartment of Cellular and Structural Biology, UT Health San Antonio, San Antonio, USAShanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Corresponding author.Objectives: SARS-CoV-2 is responsible for the global COVID-19 pandemic, with little prevention or treatment options. More than 600 million mortalities have been documented from SARS-CoV-2 infection, with the majority of fatalities occurring among elderly patients (aged >65 years). A number of vaccines have been developed in an effort to restrain the rapid spread of SARS-CoV-2. Considering the widespread administration of these vaccines, substantial side or undesired effects in multiple organ systems have emerged, necessitating essential critical care. Herein, we tabulate the adverse cardiovascular responses resulting from COVID-19 vaccines. Design or Methods: We searched PubMed for articles published through April, 2022, with the terms “SARS-CoV-2”, “COVID-19”, “cardiovascular”, “SARS-CoV-2 vaccines”, “COVID-19 vaccines”, “myocarditis”, “pericarditis”, “thrombosis”, “thrombocytopenia”, “vaccine-induced thrombotic thrombocytopenia”, “acute coronary syndrome”, “myocardial infarction”, “hypertension”, “arrythmia”, “postural orthostatic tachycardia syndrome”, “Takotsubo cardiomyopathy”, “cardiac arrest” and “death”. We mainly selected publications from the past 3 years, but did not exclude widely referenced and highly regarded older publications. Besides, we searched the reference lists of articles identified by above search method and chose those we considered relevant. Results: COVID-19 vaccines evoke rare but fatal thrombotic events, whereas messenger RNA/055based vaccines appear to be associated with risks of pericarditis/myocarditis, with the latter being more predominant in young adults following the second dose. Reports of other cardiovascular responses, including hypertension, arrhythmia, acute coronary syndrome, and cardiac arrest, have also been indicated. Conclusion: The undesired cardiovascular complications remain infrequent, giveng the large number of vaccinations inoculated to general population. And lower mortality takes precedence over the undesired cardiovascular complications.http://www.sciencedirect.com/science/article/pii/S1201971222004982SARS-CoV-2COVID-19 vaccinesCardiovascularMyocarditisPericarditisThrombotic thrombocytopenia |
| spellingShingle | Yiran E. Li Shuyi Wang Russel J. Reiter Jun Ren Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality? International Journal of Infectious Diseases SARS-CoV-2 COVID-19 vaccines Cardiovascular Myocarditis Pericarditis Thrombotic thrombocytopenia |
| title | Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality? |
| title_full | Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality? |
| title_fullStr | Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality? |
| title_full_unstemmed | Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality? |
| title_short | Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality? |
| title_sort | clinical cardiovascular emergencies and the cellular basis of covid 19 vaccination from dream to reality |
| topic | SARS-CoV-2 COVID-19 vaccines Cardiovascular Myocarditis Pericarditis Thrombotic thrombocytopenia |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222004982 |
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