| Summary: | An unprecedented novel flavanone davidone F (<b>1</b>) with a seven-membered ring side chain, and a novel flavanonol davidone G (<b>2</b>), along with 11 known flavonoids, were isolated from the ethyl acetate fraction of <i>Sophora davidii</i> (Franch.) Skeels. Their planar structures were established by UV, IR, HRESIMS, 1D and 2D NMR data. The relative configurations of <b>1</b> and <b>2</b> were determined by calculation of NMR chemical shift values, the absolute configuration of <b>1</b> and <b>2</b> were assigned by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Moreover, compounds <b>1</b>–<b>13</b> were screened for the translocation activity of glucose transporter 4 (GLUT-4), and the fluorescence intensity was increased to the range of 1.56 and 2.79 folds. Compounds <b>1</b> and <b>2</b> showed moderate GLUT-4 translocation activity with 1.64 and 1.79 folds enhancement, respectively, at a concentration of 20 μg/mL.
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