Davidones F and G, Two Novel Flavonoids from <i>Sophora davidii</i> (Franch.) Skeels
An unprecedented novel flavanone davidone F (<b>1</b>) with a seven-membered ring side chain, and a novel flavanonol davidone G (<b>2</b>), along with 11 known flavonoids, were isolated from the ethyl acetate fraction of <i>Sophora davidii</i> (Franch.) Skeels. Th...
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MDPI AG
2021-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/14/4182 |
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| author | Ping Song Xuecui Li Tongxi Zhou Yu Peng Ho-Young Choi Yuanren Ma Xinzhou Yang |
| author_facet | Ping Song Xuecui Li Tongxi Zhou Yu Peng Ho-Young Choi Yuanren Ma Xinzhou Yang |
| author_sort | Ping Song |
| collection | DOAJ |
| description | An unprecedented novel flavanone davidone F (<b>1</b>) with a seven-membered ring side chain, and a novel flavanonol davidone G (<b>2</b>), along with 11 known flavonoids, were isolated from the ethyl acetate fraction of <i>Sophora davidii</i> (Franch.) Skeels. Their planar structures were established by UV, IR, HRESIMS, 1D and 2D NMR data. The relative configurations of <b>1</b> and <b>2</b> were determined by calculation of NMR chemical shift values, the absolute configuration of <b>1</b> and <b>2</b> were assigned by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Moreover, compounds <b>1</b>–<b>13</b> were screened for the translocation activity of glucose transporter 4 (GLUT-4), and the fluorescence intensity was increased to the range of 1.56 and 2.79 folds. Compounds <b>1</b> and <b>2</b> showed moderate GLUT-4 translocation activity with 1.64 and 1.79 folds enhancement, respectively, at a concentration of 20 μg/mL. |
| first_indexed | 2024-03-10T09:30:57Z |
| format | Article |
| id | doaj.art-db138b6d5bbe4be68a2810b7d95eedd0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:30:57Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-db138b6d5bbe4be68a2810b7d95eedd02023-11-22T04:29:47ZengMDPI AGMolecules1420-30492021-07-012614418210.3390/molecules26144182Davidones F and G, Two Novel Flavonoids from <i>Sophora davidii</i> (Franch.) SkeelsPing Song0Xuecui Li1Tongxi Zhou2Yu Peng3Ho-Young Choi4Yuanren Ma5Xinzhou Yang6School of Chemistry and Chemical Engineering, Qinghai Nationalities University, Xining 810007, ChinaSchool of Chemistry and Chemical Engineering, Qinghai Nationalities University, Xining 810007, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaCollege of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaAn unprecedented novel flavanone davidone F (<b>1</b>) with a seven-membered ring side chain, and a novel flavanonol davidone G (<b>2</b>), along with 11 known flavonoids, were isolated from the ethyl acetate fraction of <i>Sophora davidii</i> (Franch.) Skeels. Their planar structures were established by UV, IR, HRESIMS, 1D and 2D NMR data. The relative configurations of <b>1</b> and <b>2</b> were determined by calculation of NMR chemical shift values, the absolute configuration of <b>1</b> and <b>2</b> were assigned by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Moreover, compounds <b>1</b>–<b>13</b> were screened for the translocation activity of glucose transporter 4 (GLUT-4), and the fluorescence intensity was increased to the range of 1.56 and 2.79 folds. Compounds <b>1</b> and <b>2</b> showed moderate GLUT-4 translocation activity with 1.64 and 1.79 folds enhancement, respectively, at a concentration of 20 μg/mL.https://www.mdpi.com/1420-3049/26/14/4182<i>Sophora davidii</i> (Franch.) Skeelsflavonoidselectronic circular dichroism (ECD)glucose transporter 4 (GLUT-4) |
| spellingShingle | Ping Song Xuecui Li Tongxi Zhou Yu Peng Ho-Young Choi Yuanren Ma Xinzhou Yang Davidones F and G, Two Novel Flavonoids from <i>Sophora davidii</i> (Franch.) Skeels Molecules <i>Sophora davidii</i> (Franch.) Skeels flavonoids electronic circular dichroism (ECD) glucose transporter 4 (GLUT-4) |
| title | Davidones F and G, Two Novel Flavonoids from <i>Sophora davidii</i> (Franch.) Skeels |
| title_full | Davidones F and G, Two Novel Flavonoids from <i>Sophora davidii</i> (Franch.) Skeels |
| title_fullStr | Davidones F and G, Two Novel Flavonoids from <i>Sophora davidii</i> (Franch.) Skeels |
| title_full_unstemmed | Davidones F and G, Two Novel Flavonoids from <i>Sophora davidii</i> (Franch.) Skeels |
| title_short | Davidones F and G, Two Novel Flavonoids from <i>Sophora davidii</i> (Franch.) Skeels |
| title_sort | davidones f and g two novel flavonoids from i sophora davidii i franch skeels |
| topic | <i>Sophora davidii</i> (Franch.) Skeels flavonoids electronic circular dichroism (ECD) glucose transporter 4 (GLUT-4) |
| url | https://www.mdpi.com/1420-3049/26/14/4182 |
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