Osteoimmune interactions in inflammatory bowel disease : central role of bone marrow Th17 TNFα cells in osteoclastogenesis
Osteoimmunology is an interdisciplinary research field dedicated to the study of the crosstalk between the immune and bone systems. CD4+ T cells are central players in this crosstalk. There is an emerging understanding that CD4+ T cells play an important role in the bone marrow under physiological a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00640/full |
| _version_ | 1828525320947367936 |
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| author | Abdelilah eWakkach Matthieu eRouleau Claudine eBlin-Wakkach |
| author_facet | Abdelilah eWakkach Matthieu eRouleau Claudine eBlin-Wakkach |
| author_sort | Abdelilah eWakkach |
| collection | DOAJ |
| description | Osteoimmunology is an interdisciplinary research field dedicated to the study of the crosstalk between the immune and bone systems. CD4+ T cells are central players in this crosstalk. There is an emerging understanding that CD4+ T cells play an important role in the bone marrow under physiological and pathological conditions, and modulate the differentiation of bone-resorbing osteoclasts. However, identification of the mechanisms that maintain CD4+ T cells in the bone marrow is still a matter of investigation. This article describes the CD4+ T cell populations of the bone marrow and reviews their role as osteoclastogenic population in inflammatory bowel disease. |
| first_indexed | 2024-12-11T21:03:37Z |
| format | Article |
| id | doaj.art-db13ad2148dc40f2926607f5769fe036 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T21:03:37Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-db13ad2148dc40f2926607f5769fe0362022-12-22T00:50:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-12-01610.3389/fimmu.2015.00640170258Osteoimmune interactions in inflammatory bowel disease : central role of bone marrow Th17 TNFα cells in osteoclastogenesisAbdelilah eWakkach0Matthieu eRouleau1Claudine eBlin-Wakkach2CNRS-UMR7370CNRS-UMR7370CNRS-UMR7370Osteoimmunology is an interdisciplinary research field dedicated to the study of the crosstalk between the immune and bone systems. CD4+ T cells are central players in this crosstalk. There is an emerging understanding that CD4+ T cells play an important role in the bone marrow under physiological and pathological conditions, and modulate the differentiation of bone-resorbing osteoclasts. However, identification of the mechanisms that maintain CD4+ T cells in the bone marrow is still a matter of investigation. This article describes the CD4+ T cell populations of the bone marrow and reviews their role as osteoclastogenic population in inflammatory bowel disease.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00640/fullBone MarrowInflammatory Bowel DiseasesOsteoclastsOsteoporosisTh17 Cellsosteoimmunology |
| spellingShingle | Abdelilah eWakkach Matthieu eRouleau Claudine eBlin-Wakkach Osteoimmune interactions in inflammatory bowel disease : central role of bone marrow Th17 TNFα cells in osteoclastogenesis Frontiers in Immunology Bone Marrow Inflammatory Bowel Diseases Osteoclasts Osteoporosis Th17 Cells osteoimmunology |
| title | Osteoimmune interactions in inflammatory bowel disease : central role of bone marrow Th17 TNFα cells in osteoclastogenesis |
| title_full | Osteoimmune interactions in inflammatory bowel disease : central role of bone marrow Th17 TNFα cells in osteoclastogenesis |
| title_fullStr | Osteoimmune interactions in inflammatory bowel disease : central role of bone marrow Th17 TNFα cells in osteoclastogenesis |
| title_full_unstemmed | Osteoimmune interactions in inflammatory bowel disease : central role of bone marrow Th17 TNFα cells in osteoclastogenesis |
| title_short | Osteoimmune interactions in inflammatory bowel disease : central role of bone marrow Th17 TNFα cells in osteoclastogenesis |
| title_sort | osteoimmune interactions in inflammatory bowel disease central role of bone marrow th17 tnfα cells in osteoclastogenesis |
| topic | Bone Marrow Inflammatory Bowel Diseases Osteoclasts Osteoporosis Th17 Cells osteoimmunology |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00640/full |
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